The northern region of the Republic is in the Khorezm regionthat Khorezm– 150 cotton variety was irrigated three times in 70–75–65% of the field capacity moisture and 4 times in the 75–75–65% system. In the 75–75–65% irrigation range, the yield of cotton was lower than in the 70–75–65% range compared to the field moisture capacity. When 70–75–65% of the fieldcapacity moisture content, fertilizer standard N–200; P–140 and K–100 kg/ha variants had a high yield of 35,4 ct/ ha. From the results of the study the following conclusions are reached that irrigation of medium– fiber cotton of Khorezm–150 with humidity 70–75–65%, It is best to give that fertilizer standard N–200; P–140; K–100 kg/ha.