In this article, in the conditions of saline soils of Bukhara region in the cultivation of winter wheat variety Krasnodar-99 pre-irrigation soil moisture is 70-80-70% relative to the limit field moisture capacity, the rate of mineral fertilizers is N240; P180; When applied at the rate of K90 kg / ha, the amount of water used for irrigation was saved by 1934 m3 / ha, which allowed to obtain an additional yield of 9.2-11.8 t / ha of wheat, and the accumulation of salts in the soil was 0.27-0.21% less than the control option.