In the conditions of Surkhandarya region, the use of growth stimulants Uzgumi and Masuda for obtaining a high-quality crop of repeated soybean crops of the Nafis variety was studied. When using the growth stimulator Uzgumi is recommended (seed treatment rate of 0,6 l/t; spraying plants in the phase of 3-5 leaves 0,2 l/ha, in budding 0,3 l/ha, and in flowering 0,4 l/ha) and the stimulator Masuda (seed treatment rate of 3,0 l/t; and spraying plants in the phase of 3-5 leaves 6,0 l/ha; in budding 9,0 l/ha) had a positive effect on growth and development, and soybean yield.