In the conditions of takyr-like soils with signs of alluvial growth in the Surkhandarya region, the use of defoliant Liquid KMD with a rate of 8.0-9.0 l / ha and UzDEF with a rate of 7.0-8.0 l / ha for opening of bolls of 30-40% and 40-50% on fine-fiber cotton variety Termiz-202, depending on leaf maturation and opening of bolls, the yield of raw cotton averaged 34.6-35.2 c / ha and 34.8-35.9 c / ha.