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ТОШКЕНТ ШАҲРИДАГИ ЎЗБЕК МИЛЛАТИГА МАНСУБ АЁЛЛАРДА ЦЕРВИКАЛ ИНТРАЭПИТЕЛИАЛ НЕОПЛАЗИЯ РИВОЖЛАНИШИДА TP53 ГЕНИНИНГ ARG72PRO ЛОКУСИ

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MAQOLA ANNOTATSIYASI

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Цервикал интраэпителиал неоплазия (cervical intraepithelial neoplasia (CIN)) бўлган 226 та бемор аёллар ва 165 та шартли соғлом аёллар орасида TP53 гени Arg72Pro полиморфизми генотиплари таҳлили ўтказилганида, Arg/ Arg гомозиготли генотипи устидан Pro аллель ва кам учрайдиган Pro/Pro мутант гомозиготли генотип юқорилиги аниқланган. CIN оғирлиги ортиши қуйидаги ҳолларда кам учрайдиган Pro/Pro мутант гомозиготли генотип учраши ортиши билан боғлиқ: енгил интраэпителиал шикастланишларда (Lowgrade Squamous Intraepitelial Lesions (LSIL)) - Pro/Pro генотипи учраши 18,28% (ОR = 1,422); ясси ҳужайрали интраэпителиал зарарланишининг юқори даражасида (Highgrade Squamous Intraepitelial Lesions (HSIL) CIN ΙΙ 56,25% (ОR = 7,938); HSIL CIN ΙΙΙ да 75,00% (ОR = 18,522). Pro аллель мавжудлиги CIN оғирлиги ортиши билан боғлиқлиги ушбу аллелга эга бўлган генотиплар CIN оғирлиги ортиши хавф омили эканлигидан далолат беради.

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# cervical cancer# интраэпителиальная неоплазия шей# рак шейки матки# локус Arg72Pro# ген TP53# интраэпителиал цервикал неоплази# бачадон бўйни раки# ген ТР53# cervical intraepithelial neoplas# locus Arg72Pro# gene TP53

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Foydalanilgan adabiyotlar

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