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ИРИДОИДЛАРНИНГ ГЕПАТОПРОТЕКТОРЛИК ФАОЛЛИГИНИ МИҚДОРИЙ НИСБАТ ТУЗИЛИШИ ФАОЛЛИГИ (МНТФ) УСУЛИ АСОСИДА ЎРГАНИШ

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MAQOLA ANNOTATSIYASI

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Мазкур тадқиқот иши миқдорий нисбат тузилиши фаоллигини (МНТФ) қўллаш орқали 10 та иридоиднинг гепатопротекторлик фаоллигини коррелация ва башорат қилишни ўрганишга бағишланган. Иридоидлар ўсимликнинг турли қисмларида учрайдиган монотерпеноидларнинг энг катта синфи ҳисобланади. Квант-кимёвий дискрипторлар ярим эмперик RM1 усулини қўллаш орқали ҳисобланди. Олинган модель иридоидларнинг гепатоҳимоя фаоллигини ёритиш учун фойдали ва уни янги иридоидларнинг гепатопротекторлик фаоллигига баҳо беришда қўлласа бўлади. Тадқиқотлар натижасида олинган модель нафақат яхши статистик кўрсаткич, балки яхши башорат қилиш қобилиятини ҳам кўрсатди. Моделнинг башорат қилиш кўрсаткичи (r2test) 0,99 ни ташкил қилади.

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# гепатопротекторная активность# hepatoprotective# квантово-химические расчеты# quantum-chemical calculations# иридоидлар# гепатопротекторлик# МНТФ# башорат қилиш модели# кванткимёвий ҳисоб# иридоиды# КССА# прогнозная модель# iridoids# QSAR# predictive model

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