The study of technological features of industrial silkworm hybrids with the participation of sex-labeled lines is considered in this paper. To evaluate new hybrid combinations of silkworms according to technological features, 300-400 samples each of hybrids were taken from a mixture of cocoons. Samples of cocoons were frozen and pupae are killed at high temperature and dried in the shade. Unwinding tests were made at the Scientific Research Institute of Natural Fibers (Uzbekistan) and the leading technological indicators were determined, such as the yield of raw silk, the yield of all silk products, the unwinding of cocoons, the length of the continuously unwound thread, the total length of the thread, the metric number of the cocoon thread, and the specific consumption of cocoons to obtain 1 kg of raw silk. Based on the results of a three-year comparative study of eight silkworm hybrids, two reciprocal hybrids Line 32 mech x Line 101 and Line 101 x Line 32 mech were identified, which have high rates of raw silk (46.56-47.34%), cocoon unwinding (91.3-93.3%), total thread length (1540-1637 m), and metric thread number (3369-3478 m/g). It was concluded that it is expedient to use sex-labeled silkworm lines as parental components in the grain production of Uzbekistan.