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Перитонитда янги махаллий оқсил-туз қон урнини босувчисини таъсир самарадорлигини урганиш

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MAQOLA ANNOTATSIYASI

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A new original domestic multifunctional blood substitute «Yantaroprotein» was developed at the Scientific Research Institute of Hematology and Blood Transfusion of the Ministry of Health of the Republic of Uzbekistan. «Yantaroprotein» – providing immunomodulating, gemostimulating, antiinflammatory, antitumor and antioxidant effect, which has the ability to restore metabolic processes at the cellular and tissue levels in critical conditions. Research objective – The experiments were performed on a model of experimental peritonitis on 90 rats weighing 180 ± 250 grams. The indices of endogenous intoxication, the state of LPO and AOS of blood were studied. This work presents the results of a study of the new blood substitute in peritonitis. Studied parameters of endogenous intoxication state of lipid peroxidation (LPO) and antioxidant levels. A new blood substitute preparation for infusions of «Yantaroprotein» of local production leads to normalization of endogenous intoxication, LPO and AOS recovery, more effective than the drug «Lactoprotein» used in medical practice, which allows it to be recommended in the complex treatment of peritonitis.

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Teglar

# эндоген интоксикация# endogenous intoxication# «Янтаропротеин»# экспериментальный перитонит# эндогенная интоксикация# перекисное окисление липидов (ПО# антиоксидантная система (АОС).# “Янтаропротеин”# экспериментал перитонит# липидларни пероксид оксидланиши # антиоксидант тизимини (АОТ)# «Yantaroprotein»# lipid peroxidation (LPO)# antioxidant system (AOS)

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Maqola idintifikatorlari

Foydalanilgan adabiyotlar

1. Aliev R. H., Karimov H. Ja., & Shevchenko L.I. (2011). Vlijanie novogo otechestvennogo krovezamenitelja jantaroproteina na belkovoj i azotistyj obmen pri belkovom golodanii. [Influence of a new domestic blood-substituting infusion drug «Yantaroprotein» on protein and nitrogen metabolism in protein starvation]. 70 let NII gematologii i perelivanija krovi MZ RUz «Sovremennye metody diagnostiki, lechenija zabolevanij sistemy krovi i problemy transfuziologii» 27-28 oktjabrja – Tashkent. Sb. nauch.tr., 88-89.

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3. Kopytova T. V, Dmitrieva O. N., Himkina L. N., & Panteleeva G. A.. (2009). Okislitel’naja modifikacija belkov i oligopeptidov u bol’nyh hronicheskimi dermatozami s sindromom jendogennoj intoksikacii [Oxidative modification of proteins and oligopeptides in patients with chronic dermatoses with the syndrome of endogenous intoxication]. Fundamental’nye issledovanija, (6), 25-29.

4. Men’shhikova E. B., Zenkov N. K., Lankin V. Z., Bondar’ I. A., & Trufakin V. A. (2008). Okislitel’nyj stress: Patologicheskie sostojanija i zabolevanija [Oxidative stress: Pathological conditions and diseases]. Novosibirsk «APTA», 284.

5. Shevchenko L. I., Karimov H. Ja., & Memetov F. Ju. (2010). Sostav krovezamenitelja «Jantaroproteina» [Composition of the blood substitute «Yantaroprotein»]. Agentstvo po intellektual’noj sobstvennosti Respubliki Uzbekistan. Zajavka № IAP 20100433. 08.09.2010 g.

6. Kusano C., Ferrari B. (2008). Total Antioxidant Capacity: a biomarker in biomedical and nutritional studies. – J. Cell. Mol. Biol., 7(1), 1-15.

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