logo
calendar25 ноябр 2019
view2
Asosiy til:O'zbek

БИРЛАМЧИ ДИАГНОЗНИ ҚЎЙИШ УЧУН ЛЕЙКОЗ БЕМОРЛАРНИ МОЛЕКУЛЯР-ГЕНЕТИК МАРКЕРЛАРГА ТЕКШИРИШ

Fan yo'nalishi:
pdf

file.pdf

PDF

MAQOLA ANNOTATSIYASI

quote
The article discusses molecular genetic studies of markers for the diagnosis of primary leukemia based on biochip technology. The study included 2,600 gene translocations of 250 patients diagnosed with acute leukemia. Of these, 13 (26%) had a chimeric gene (t(9;22) BCR/ABL p190(7%), t(9;22) BCR/ABL p210(14%), t(10;11) MLL/AF10(7%),t(15;17) PML/RARA bcr-2(14%), t(8;21) AML/ ETO(38%), KMT2A (MLL-PTD-9)(7%) and KMT2A (MLL-PTD-10) (7%)) presence of DNA molecules, the relevant recommendations were given.

MUALIFLAR

Teglar

# Лейкоз# биочип# бирламчи диагноз# молекуляр-генетик маркерлар# первичный диагноз# молекулярно-генетические маркеры# Leukemia# biochip# primary diagnosis# molecular genetic markers

Maqolani baholang

0

0 ta

Maqola idintifikatorlari

Foydalanilgan adabiyotlar

1.Amanda C. Wintersand Kathrin M. Bernt. MLL-Rearranged Leukemias—An Update on Science and Clinical Approaches. FrontPediatr. 2017; 5: 4.Р 3-25. doi: 10.3389/fped.2017.00004.

2.Annette Fasan, Claudia Haferlach, Karolina Perglerovà, Wolfgang Kern, and TorstenHaferlach. Molecular landscape of acute promyelocytic leukemia at diagnosis and relapse. Haematologica. 2017 Jun; 102(6): e222–e224.doi:10.3324/haematol.2016.162206.

3.Chai-AdisaksophaC,LamW,HillisC.Major arterial events in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors: a meta-analysis.Leuk Lymphoma.2016;57(6):1300-10. doi: 10.3109 / 10428194.2015.1091929

4.Daniel A. Arber, AttilioOrazi, Robert Hasserjian, Jürgen Thiele, Michael J. Borowitz, Michelle M. Le Beau, Clara D. Bloomfield, Mario Cazzola and James W. Vardiman. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia Blood 2016 127:2391-2405. https://doi.org/10.1182/blood-2016-03-643544

5.Douxfils J, Haguet H, Mullier F, Chatelain C, Graux C, Dogné JM. Association Between BCR-ABL Tyrosine Kinase Inhibitors for Chronic Myeloid Leukemia and Cardiovascular Events, Major Molecular Response, and Overall Survival: A Systematic Review and Meta-analysis.JAMA Oncol. 2016; 2 (5): 625-632. DOI: 10,1001 / jamaoncol.2015.5932

6.Haery L, Thompson RC, Gilmore TD. Histone acetyltransferases and histone deacetylases in Band T-cell development, physiology and malignancy. GenesCancer. 2015;6:184–213. doi: 10.18632/ genesandcancer.65.

7.HartmutDöhner, ElihuEstey, David Grimwade, Sergio Amadori, Frederick R. Appelbaum, Thomas Büchner, HervéDombret, Benjamin L. Ebert, Pierre Fenaux, Richard A. Larson, Ross L. Levine, Francesco Lo-Coco, Tomoki Naoe, DietgerNiederwieser, Gert J. Ossenkoppele, Miguel Sanz, Jorge Sierra, Martin S. Tallman, Hwei-Fang Tien, Andrew H. Wei, Bob Löwenberg, and Clara D. Bloomfield. Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel. Blood. 2017 Jan 26; 129(4): 424–447.doi:10.1182/blood-2016-08-733196.

8.Hua Yang, Sai Huang, Cheng-Ying Zhu, Li Gao, Hai-Yan Zhu, Na Lv, Yu Jing, and Li Yu. The Superiority of Allogeneic Hematopoietic Stem Cell Transplantation Over Chemotherapy Alone in the Treatment of Acute Myeloid Leukemia Patients with Mixed Lineage Leukemia (MLL) Rearrangements. MedSciMonit. 2016; 22: 2315–2323.doi:10.12659/MSM.899186.

9.Lo-Coco F, Hasan SK. Understanding the molecular pathogenesis of acute promyelocytic leukemia. Best Pract Res ClinHaematol. 2014;27(1):3–9.doi: 10.1016 / j.beha.2014.04.006.

10.Madan V, Shyamsunder P, Han L, et al.Comprehensive mutational analysis of primary and relapse acute promyelocytic leukemia. Leukemia. 2016;30(12):2430. doi: 10.1038/leu.2016.237.

11.Mandoli A, Singh AA, Prange KHM, Tijchon E, Oerlemans M, Dirks R, Menno TH, Wierenga ATJ, Jansses-Megens EM, Berentsen K, Sharifi N, Kim B, Matarese F, Nguyen LN, Hubner NC, Rao NA, van den Akker E, Altucci L, Vellenga E, Stunnenberg HG, Martens JHA. The Hematopoietic Transcription Factors RUNX1 and ERG Prevent AML1-ETO Oncogene Overexpression and Onset of the Apoptosis Program in t(8;21) AMLs. CellReports. 2016 Nov 15;17:1–14.doi: 10.1016 / j.celrep.2016.08.082

12.María-José Bañuls , Sergi B. Morais , Luis A. Tortajada-Genaro , and ÁngelMaquieira, Microarray Technology: Methods and Applications, Methods in Molecular Biology, vol. 1368, © Springer Science+Business Media New York 2016. p 37-51, DOI 10.1007/978-1-4939-3136-1_4

13.Martens JH, Mandoli A, Simmer F, Wierenga BJ, Saeed S, Singh AA, Altucci L, Vellenga E, Stunnenberg HG. ERG and FLI1 binding sites demarcate targets for aberrant epigenetic regulation by AML1-ETO in acute myeloid leukemia. Blood. 2012 Nov 8;120:4038–48.doi: 10.1182 / blood-2012-05-429050.

14.Rieko Taniguchi, Hideki Muramatsu, Yusuke Okuno, Kyogo Suzuki, Satoshi Obu, Masahiro Nakatochi, TeppeiShimamura, Yoshiyuki Takahashi, YasuoHorikoshi, Kenichiro Watanabe and Seiji Kojima. Comprehensive genetic analysis of donor cell derived leukemia with KMT2Arearrangement. Pediatric Blood & Cancer. 2017. №4 P 1-5. DOI: 10.1002/pbc.26823.

15.Tamai H, Inokuchi K. 11q23/MLL acute leukemia: update of clinical aspects. J ClinExpHematop. 2010;50:91–98.

16.ValentP,HadzijusufovicE,SchernthanerGH,etal.Vascular safety issues in CML patients treated with BCR/ABL1 kinase inhibitors. Blood. 2015;125(6):901-6.doi: 10.1182 / blood-2014-09-594432.

17.Руководство по применению набора реагентов для выявления и идентификации хромосомных транслокаций при острых и хронических лейкозах методом гибридизации на биологических микрочипах «лк-биочип». 2009 год. www.biochip-imb.ru/attachments/article/27. pdf

18.http://www.interlabservice.ru/catalog/reagents/?sid=1403&id=6489

19.https://omim.org/entry/102578?search=PML/RARA&highlight=pml%20pmlrara%20rara

20.https://omim.org/entry/133435?search=AML/ETO&highlight=amleto%20aml%20eto

21.https://omim.org/entry/151410_ BCR / ABL FUSION GENE

22.https://omim.org/entry/159555_MLL/AF10

23.https://omim.org/search/?index=entry&search=leukemia&sort=score+desc%2C+prefix_ sort+desc&start=139&limit=10

public

SLIB.uz — O'zbekiston ilmiy jurnallari va maqolalar yagona tizimda ilmiy nashirlarni bir joyda ko'rish, izlash va ulardan foydalanish imkonini beruvchi zamonaviy platforma.

Ijtimoiy tarmoqlarda
instagramtelegramyoutubefacebook

Bog'lanish uchun

Manzil:Chilonzor tumani Qatortol ko'chasi 60B

Tel:+998(55)511-44-00

Savol-javob va takliflar uchun

© 2026 Barcha huquqlar himoyalangan.