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Ўзбек популяциясида юрак ишемик касаллиги билан GLUT9, URAT1 генларининг ягона нуклеотид полиморфизмлари ассоциациясини тадқиқ килиш

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Ушбу тадқиқотнинг мақсади ўзбек популяциясида ЮИК ривожланишида GLUT9, URAT1 генларининг ягона нуклеотид полиморфизмлари таъсирини ўрганишдир. Тадқиқотга ишемик юрак касаллиги билан оғриган 106 нафар бемор ва 64 та назорат гурухида бўлган индивидлар кирган. GLUT9 (rs52448471), URAT1 (rs3825016) полиморфизми полимераза занжир реакция протоколи ёрдамида генотипланди ва рестрикцион фрагментлар узунли полиморфизмини аниқланди. Статистик тахлил ЮИКнинг беқарор шакллари билан глюкозани ташувчиси GLUT9 гени Т/Т аллел вариантни ахамиятли боғлиқ бўлганлиги аниқлади. URAT1 генининг Т/Т варианти касалликнинг барқарор шакли билан боғлиқ эди. Тадқиқот натижалари GLUT9 ва URAT1 генининг полиморф вариантлари ўзбек популяциясининг ишемик юрак касаллиги ривожланишида ахамиятлигини кўрсатди.

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# юрак ишемик касаллиги# ишемическая болезнь сердца# однонуклеотидный полиморфизм# GLUT9# URAT1# Coronary heart disease# single nucleotide polymorphism# ягона нуклеотид полиморфизм

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Foydalanilgan adabiyotlar

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