In the Zarafshan valley in the conditions of irrigated agriculture for the cultivation of durum wheat, depending on the biological properties, autumn varieties were planted in the first ten days of October and mineral fertilizers in the amount of N210P147Kl05 kg per hectare, for spring varieties - mineral fertilizers in the amount of N180P126K90 kg per hectare in the second decade of October (16.10), which ensures a high grain yield.