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PSEUDOALTEROMONAS SP.НИНГ 1020R ШТАММ БАКТЕРИЯ ПРОДИГИОСИН ҚАТОРИ МОДДАЛАРИНИНГ ПРОТЕИНФОСФАТАЗА ВА ПРОТЕИНКИНАЗА ФЕРМЕНТ ФАОЛЛИКЛАРИГА ТАЪСИРИ

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MAQOLA ANNOTATSIYASI

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Pseudoalteromonas sp.нинг 1020R штаммга оид бактерия продигиосин ва унинг ён алкил занжирлари узунлиги билан фарқланувчи турдош ҳосилалар синтез қилади. Ушбу қизилпигментли бирикмалар одамлейкемия ҳужайра линияларига қарши цитотоксик таъсир кўрсатиши аниқланди. Шунингдек, бирикмалар, дозага боғлиқ равишда протеинфосфатаза 2А ва протеинтирозинфосфатаза 1В (PTP1B)ларга ингибирловчи таъсир кўрсатиб, протеинкиназбилан бирга протеинтирозинкиназ, Са2+/кальмодулинга боғлиқ протеинкиназа ва протеинкиназа А ва С ларга нисбатан фаоллик кўрсатмади. PTP1B ферментини ингибирлаши бўйича пигмент бирикмаларнинг алоҳида ўрганиш натижалари кўрсатдики, C-3 ҳолатида алкил занжири узунлиги ортиши билан, аралашмаларнинг ингибиторлик таъсири камаяди. Натижалар продигиосин оиласига мансуб моддаларнинг ҳавфли ўсма хужайраларига қарши цитотоксик таъсирида протеинкиназалардан кўра протеинфосфатазалар кўпроқ иштирок этиши ҳақида ҳулоса беради.

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# цитотоксичность# ингибирование ферментов# структурозависимая активность# cytotoxicity# enzyme inhibition# structure dependent activity# цитотоксиклик# ферментларингибирланиши# структурага боғлиқ фаоллик

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4. Pandey R., Chander R., Sainis K.B. Prodigiosins as anti-cancer agents: living up to their name. Curr. Pharm. Des., 2009;15:732–41.

3. Montaner B., Pérez-TomásR. The prodigiosins: a new family of anticancer drugs. Curr. Cancer Drug Target, 2003;3:57– 65.

1. Wang Y., Nakajima A., Hosokawa K., et al. Cytotoxic prodigiosin family pigments from Pseudoalteromonassp. 1020R isolated from the Pacifc coast of Japan. Biosci.Biotechnol.Biochem., 2012;76:1229–32.

2. Williamson N.R., Fineran P.C., Gristwood T., et al. Anticancer and immunosuppressive properties of bacterial prodiginines. Future Microbiol., 2007;2:605–18.

5. Fürstner A., Reinecke K., Prinz H., Waldmann H. The core structures of roseophilin and the prodigiosin alkaloids defne a new class of protein tyrosine phosphatase inhibitors. ChemBioChem, 2004;5:1575–9.

6. Toomik R., Ek P. A potent and highly selective peptide substrate for protein kinase C assay. Biochem. J., 1997;322:455–60.

7. Ravi R., Jain A.J., Schulick R.D., et al. Elimination of hepatic metastases of colon cancer cells via p53-independent crosstalk between irinotecan and Apo2 Ligand/TRAIL. Cancer Res., 2004;64:9105–14.

8. Castillo-Ávila W., Abal M., Robine S., Pérez-TomásR. Non-apoptoticconcentrations of prodigiosin (H+/Cl-symporter) inhibit theacidifcation of lysosomes and induce cell cycle blockage in coloncancer cells. Life Sci., 2005;78:121–7.

9. Montaner B., Navarro S., Piqué M., et al. Prodigiosin from thesupernatant of Serratiamarcescensinduces apoptosis in haematopoietic cancer cell lines. Br. J.Pharmacol., 2000;131:585–93.

10. Soto-Cerrato V., Vinãls F., Lambert J.R., Pérez-Tomás R. Theanticancer agent prodigiosin induces p21WAF1/CIP1expression viatransforming growth factor-beta receptor pathway. Biochem.Pharmacol., 2007;74:1340–9.

11. Ju J.F., Banerjee D., Lenz H.J. et al. Restoration of wild-type p53activity in p53-null HL-60 cells confers multidrug sensitivity. Clin.Cancer Res. 1998;4:1315–22.

12. Feinstein E., Gale R.P., Reed J., Canaani E. Expression of the normalp53 gene induces differentiation of K562 cells. Oncogene, 1992;7:1853–7.

13. Yu J.L., Rak J.W., CoomberB.L.,et al. Effect of p53 status on tumorresponse to antiangiogenic therapy. Science, 2002;295:1526–8.

14. Ramoneda B.M., Pérez-TomásR. Activation of protein kinase C forprotection of cells against apoptosis induced by the immunosuppressor prodigiosin. Biochem.Pharmacol., 2002;63:463–9.

15. Zhang S., Zhang Z.-Y. PTP1B as a drug target: recent developmentsin PTP1B inhibitor discovery. Drug Discov. Today, 2007;12:373–81.

16. Combs A.P. Recent advances in the discovery of competitive proteintyrosine phosphatase 1B inhibitors for the treatment of diabetes,obesity, and cancer. J. Med. Chem., 2010;53:2333–44.

17. Stuible M., Doody K.M., Tremblay M.L. PTP1B and TC-PTP: regulators of transformation and tumorigenesis. Cancer Metastasis Rev. 2008;27:215–30.

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