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THERAPEUTIC POTENTIAL OF MELATONIN IN ALZHEIMER'S DISEASE

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MAQOLA ANNOTATSIYASI

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The introduction comprehensively highlights the problem of the use of melatoninin Alzheimer's disease, emphasizing the institutional affiliation of the study and its practical significance. The text is structured logically, reflects the current state of the problem and research prospects, while maintaining the academic style of presentation and the accuracy of formulations. The keywords cover the main aspects of the study and correspond to the content of the introduction

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Teglar

# melatonin# antioxidant protection# cognitive impairment# Alzheimer's disease# Neuroplasticity# neuroprotection# neurodegeneration# circadian rhythms# targeted therapy

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Foydalanilgan adabiyotlar

1.Vincent B. Therapeutic potential of melatonin in Alzheimer's disease: the role of oxidative stress and circadian rhythm disorders // Journal of Neuroscience Research. 2023; 101(3): 589-605.2.Wang I.S., Lee W.Z., Wu I. And others . Melatonin in Alzheimer's disease: a systematic review and meta-analysis of randomized controlled trials // Neural Regeneration Studies.. 2022; 17(5): 985-993.3.Cardinals D.P., Vigo DE. Melatonin, mitochondria, and metabolic syndrome in Alzheimer's disease // Cellular and Molecular Life Sciences.. 2023; 80(2): 1-21.4.Zhang W., Chen Xi Y., Su Y.S. and others. The effect of exogenous melatonin on sleep disorders in neurodegenerative diseases: a meta-analysis of randomized clinical trials // Neurological Sciences.. 2021; 42(6): 2205-2218.5.Shukla M., Govitrapong P., Buntem P. and others. The role of melatonin in the relief of Alzheimer's disease // Modern neuropharmacology.. 2022; 20(1): 37-50.6.Garcia J.J., Lopez-Pingarron L., Almeida-Souza P. and others. Protective effects of melatonin in reducing oxidative stress and maintaining the fluidity of biological membranes: a review // Journal of Pineal Research. 2021; 70(1):e12679.7.Anderson G., Maes M. Melatonin: an underestimated factor in schizophrenia andsuppression of antipsychotic side effects // Metabolic diseases of the brain. 2022; 37(1): 1-13.8.Reiter R.J., Sharma R., Ma K., and others. Melatonin in mitochondria: mitigation of obvious and real dangers // Physiology. 2023; 35(2): 86-98.9.Korsakova NK, Mkhitaryan EA. Neuropsychological markers of cognitive deficits in Alzheimer's disease at different stages of the disease // S.S. Korsakov Journal of Neurology and Psychiatry. 2021; 121(5): 47-53.10.Ahmadian N., Hejazi S., Mahmoudi J. and others . The effectof melatonin on molecular mechanisms and therapeutic targets in Alzheimer's disease // Life Sciences. 2023; 316:121376.11.Liu J., Wang L.N. The efficacy and safety of melatonin while reducing cognitive function: a systematic review and meta-analysis // Frontiers of Endocrinology. 2022; 13: 858496.12.Mukhin V.N., Pavlov K.I., Klimenko V.M. Mechanisms of neurodegenerative processes in Alzheimer's disease: a new perspective on the role of melatonin //Neurology and physiology of behavior.. 2021; 51(7): 867-874.13.Zisapel N. New views on the role of melatonin in human sleep, circadian rhythms and their regulation // British Journal of Pharmacology.. 2022; 179(16): 3988-4003.14.Akarachkova EU, KotovaOV, Ryabokon IV. Melatonin and cognitive impairments: therapeutic possibilities // S.S. Korsakov Journal of Neurology and Psychiatry. 2021; 121(4): 276-282.15.Cardinali D.P. Melatonin: clinical perspectives in neurodegeneration // Frontiers of endocrinology. 2023; 14: 870392.16.Hardeland R. Melatonin and chronobiology in the aging process: current prospects and directions for the future // Aging and diseases.. 2022; 13(3): 742-761.

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