COMPLEX THERAPHY EFFECT IN AUTOIMMUNE DISEASES

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25 март 2025

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COMPLEX THERAPHY EFFECT IN AUTOIMMUNE DISEASES

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Eurasian Journal of Medical and Natural Sciences

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This comprehensive observational cohort study meticulously evaluated the effectiveness and safety associated with the combination therapy of adalimumab and methotrexate in individuals diagnosed with the debilitating condition known as rheumatoid arthritis (RA). The participants in this investigation were systematically categorized into three distinct groups, each receiving different treatment regimens. The findings revealed that the synergistic combination of adalimumab and methotrexate demonstrated a statistically significant superiority over methotrexate used as a standalone treatment in achieving clinically meaningful responses, specifically measured by ACR20, ACR50, and ACR70, during a rigorous nine-month treatment period. In this context,Group IB, which was administered a higher dosage of methotrexate, displayed marginally improved rates of clinical improvement compared to Group IA; however, it is worth noting that the difference between these two groups did not reach statistical significance. As the study progressed to the nine-month mark, an impressive 88.9% of the patients belonging to Group IB successfully achieved an ACR20 response, in stark contrast to the 74.2% of participants in Group IA and the significantly lower 46% observed in the comparison group. Furthermore, analogous trends were noted in the responses corresponding to ACR50 and ACR70, reinforcing the efficacy of the combination therapy. The overall implications of this study strongly suggest that the combination therapy of adalimumab and methotrexate holds a clinically superior position when compared to methotrexate monotherapy in the treatment of rheumatoid arthritis, with the possibility that a higher dose of methotrexate could lead to even more favorable outcomes for patients in need of effective treatment options

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# rheumatoid arthritis# methotrexate# adalimumab

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https://eroi.uz/11.0201/A0325-0153

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Foydalanilgan adabiyotlar

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