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METHODS OF STUDYING THE INFLUENCE OF ENVIRONMENTAL FACTORS ON HEREDITARY GENETIC DISEASES

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Hereditary genetic diseases are caused by inherited mutations, but environmental factors can significantly influence their onset, severity, and progression. Understanding the interplay between genetics and environmental exposures is crucial for developing preventive strategies and personalized treatments. This article discusses various methods used to study the impact of environmental factors on genetic diseases, including epidemiological studies, twin studies, genome-wide association studies (GWAS), epigenetic research, and animal models. Each method provides unique insights into gene-environment interactions, contributing to the broader understanding of disease mechanisms

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# GWAS# epidemiology# Environmental factors# Hereditary genetic disea# gene-environment interaction# epigenetics# twin studies

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Foydalanilgan adabiyotlar

1.G., Jalilova Gulchekhra, N., RasulovaNilufar, N., MukhamedovaNigora, L., Kravchenko, Lenara. BIO Web of Conferences //Impact of environmental factors in current industrial development138,030412.Boomsma, D. I., Busjahn, A., & Peltonen, L. (2002). Classical twin studies and beyond. Nature Reviews Genetics, 3(11), 872-882.3.Brenner, H., Blettner, M., & Gefeller, O. (2017). Epidemiological methods in studying gene-environment interactions. International Journal of Epidemiology, 46(3), 749-758.4.Chen, H., Uryu, K., & Bi, W. L. (2019). Animal models for studying genetic and environmental interactions in disease. Current Topics in Developmental Biology, 132, 67-955.Feil, R., & Fraga, M. F. (2012). Epigenetics and the environment: Emerging patterns and implications. Nature Reviews Genetics, 13(2), 97-109.6.Lander, E. S., Linton, L. M., & Birren, B. (2001). Initial sequencing and analysis of the human genome. Nature, 409(6822), 860-921.7.Visscher, P. M., Wray, N. R., Zhang, Q., et al. (2017). 10 years of GWAS discovery: Biology, function, and translation. American Journal of Human Genetics, 101(1), 5-22.

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