GESTATIONAL PYELONEPHRITIS: COMPLICATIONS, IMMUNE ALTERATIONS, AND MATERNAL-FETAL OUTCOMES

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GESTATIONAL PYELONEPHRITIS: COMPLICATIONS, IMMUNE ALTERATIONS, AND MATERNAL-FETAL OUTCOMES

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Eurasian Journal of Medical and Natural Sciences

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Fifty pregnant women aged 18 to 36 years diagnosed with gestational pyelonephritis were enrolled in the study. Of these, 20 patients presented with acute primary pyelonephritis in either the serous or purulent inflammatory stages, while 30 were diagnosed with chronic pyelonephritis, either in remission or experiencing disease exacerbation. In cases of acute pyelonephritis, urinary tract obstruction and impaired urine drainage were common complications, which required a range of medical interventions. Specifically, ureteral catheterization was carried out in 21 cases, ureteral stents were placed in 6 patients, percutaneous nephrostomy was performed in 3, one patient underwent nephrostomy with infection source decontamination, and another required nephrectomy.Renal function parameters and indicators of endogenous toxicity were evaluated. A strong association was found between elevated levels of middle molecular weight substances (MMS) in both maternal and fetal bloodstreams, especially pronounced in purulent compared to serous forms of the infection.Autoantibodies (auto-Abs) targeting renal antigens were measured in maternal blood serum as well as in umbilical cord blood samples from the newborns. Women affected by pyelonephritis tended to exhibit lower levels of natural physiological auto-Abs, which normally contribute to fetal protection—this finding points to a potential state of mild immunosuppression during infection

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# hydronephrosis# Gestational pyelonephritis# natural autoantibodies

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https://eroi.uz/11.0201/A0525-0150

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