The Tricardion capsule is a phytotherapeutic formulation developed using extracts of three medicinal plants: Leonurus turcestanicus, Mentha × piperita (commonly referred to as peppermint), and Crataegus sanguinea Pall. (hawthorn). These plants are native to Central Asia and are widely found in various regions of Uzbekistan. Each species has a long-standing history in traditional medicine and is known for its cardiovascular, anti-inflammatory, and antispasmodic properties. This review aims to summarize the botanical characteristics, phytochemical compositions, and pharmacological effects of the three plants. The potential synergistic benefits of combining these botanical ingredients into a single capsule are also discussed. Emphasis is placed on their cardiovascular applications, which form the basis for the development of the Tricardion capsule. The article draws from regional and international scientific literature, including studies conducted by Uzbek researchers. The findings support the scientific rationale for using these plants in combination for the prevention and management of cardiovascular conditions.