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BOLALAR VA O'SMIRLARDA MIGRENDA GUMORAL IMMUNITETNING O'ZGARISHLARI

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MAQOLA ANNOTATSIYASI

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Migraine in children and adolescents is increasingly being recognized not only as a neurological disorder, but also as a condition with possible immune system involvement. This paper explores the role of humoral immunity in the pathogenesis and clinical presentation of pediatric migraine. Based on the study of 42 children aged 6 to 18 with various forms of migraine, significant differences in immunoglobulin levels and circulating immune complexes (CIC) were observed. These findings suggest the presence of immune imbalance in children with migraines, especially those with aura. Understanding the immunological aspects of migraine can contribute to improved diagnostics, prognostics, and the development of personalized therapeutic strategies

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Teglar

# circulating immune complexes# immunoglobulin G# humoral immunity# Pediatric migraine# immunoglobulin M# immune imbalance# migraine with aura# immunopathogenesis

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Foydalanilgan adabiyotlar

1.Khaitov, P.M., Pinegin B.V., YarilinA.A. Manual of Clinical Immunology: Diagnosis of Diseases of the Immune System. Moscow: GEOTAR-Media, 2009. 352 p.2.Shamansurov Sh.Sh., Gulyamova M.K., Karimova N.A. Basilar migraine in children -an object of diagnostic error. NEVROLOGIYA. 2014; 2(58): 101.3.Hermann G.E., Holmes G.M., Rogers R.S. TNF(α) modulation of visceral and spinal sensory processing. Curr Pharm Des. 2005;11(11):1391–14094.Gazerani P. et al. The role of immune and inflammatory mechanisms in migraine. J Headache Pain. 2019; 20:122. doi:10.1186/s10194-019-1069-1.5.Alstadhaug K.B. Migraine and the immune system. J Neurol Sci. 2014; 344(1–2): 3–7. doi:10.1016/j.jns.2014.06.028.6.Charles A. The pathophysiology of migraine: implications for clinical management. Lancet Neurol. 2018; 17(2): 174–182. doi:10.1016/S1474-4422(17)30435-0.

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