The article discusses anthropogenic changes in the state of the biosphere of the Aral Sea region associated with changes in the elemental composition of the natural waters of the region. It is interesting to consider the value of EF (enrichment factor) for these objects. The value of EF and WMC (Water migration coefficient) characterizes the degree of enrichment and migration abilities of chemical elements in the object. The analysis was carried out by the method of neutron activation. Received an average content of more than 30 chemical elements in the composition of natural waters