ИЗУЧЕНИЕ ИНОТРОПНОГО И АНТИАРИТМИЧЕСКОГО ДЕЙСТВИЯ НЕКОТОРЫХ ИЗОХИНОЛИНОВЫХ АЛКАЛОИДОВ

Wright S.N. Comparison of aconitine–modified human heart (hH1) and rat skeletal (micro 1) muscle Na + –channels: an important role for external Na + ions // The Journal of Physiology. – 2002. – V. 538. – P.759–771.

Grant A.O. Arrhythmia and electrophysiology // Circulation. – 2009. – V.2. – P.185-194.

Roden D.M. Antiarrhythmic drugs: from mechanisms to clinical practice // Heart. – 2000. – V.84. –Р.339-346.

Yee G.Y., Camm J. Drug induced QT prolongation and torsades de pointes// Heart. – 2003. – V.89. – Р.1363-1372.

Садиков А.З. Оптимизация технологий производства алкалоидов из растительного сырья (на примере алкалоидов дитерпеновых, изохинолиновых, индольных, пирролизидиновых и стероидных классов) //Дисс.… в виде научн. докл. – Ташкент (ИХРВ), 2015. – с. 7.

Ribeiro G.T. et al. Beneficial effects of berber- ine on early mortality after experimental coronary artery occlusion in rats // Circulation. – 1982. – V.66 (11). – P.56.

Riccioppo N.F. Electropharmacological effects of berberine on canine cardiac Purkinje fibres and ventricular muscle and atrial muscle of the rabbit // Br. J. Pharmacol. – 1993. – V.108. – P.534-537.

Grippo A.J., Santos C.M., Johnson R.F., Beltz T.G., Martins J.B., Felder R.B., Johnson A.K. Increased susceptibility to ventricular arrhythmias in a rodent model of experimental depression // Am. J. Physiol. Heart. Circ. Physiol. – 2004. – V.286. – P.H619–H626.

Amran M.S., Hashimoto K., Homma N. Effects of sodium–calcium exchange inhibitors, KB– R7943 and SEA0400, on aconitine–induced arrhythmias in guinea pigs in vivo, in vitro, and in computer simulation studies // J. Pharmacol. Exp. Ther. – 2004. – V.310. – P.83–89.

Shi-Sheng Z., Yang J., Li Y.-Q., Zhao L.- Y., Xu M., Ding Y.-F. Effect of Cl – –channel blockers on aconitine–induced arrhythmias in rat heart // Exp. Physiol. – 2005. – V.90(6).– P.865–872.

Arita J., Xue X.Y., Aye N.N., Fukuyama K., Wakui Y., Niitsu K., Maruno M., Siying C., Hashimoto K. Antiarrhythmic effects of an aconitine–like compound, TJN–505, on canine arrhythmia models // Eur. J. Pharmacol. – 1996. – V.318. – P.333–340.

Takahara A., Uneyama H., Sasaki N., Ueda H., Dohmoto H., Shoji M., Hara Y., Nakaya H., Yoshimoto R. Effects of AH–1058, a new antiarrhythmic drug, on experimental arrhyth- mias and cardiac membrane currents // J. Cardiovasc. Pharmacol. – 1999. – V. 33. – P. 625-632.

Lu H.R., Clerck D.F. R56865, a Na + /Ca 2+ – overload inhibitor, protects against aconitine induced cardiac arrhythmias in vivo. //Cardiovasc. Pharmacol. – 1993. – V.22. – P.120-125.

Peper K., Trautwein W. The effect of aco- nitine on the membrane current in cardiac muscle // Pflugers Arch GesamtePhysiol Menschen Tiere Jour- nal. – 1967. – V. 296. – P.328-336.

Catterall W.A. From ionic currents to molecu- lar mechanisms: The structure and function of volt- age–gated sodium channels // Neuron. – 2000. – V.26. –P.13–25.

Sawanobori T., Hirano Y., Hiraoka M. Aconitine–induced delayed afterdepolarization in frog atrium and guinea pig papillary muscles in the presence of low concentrations of Ca 2+ // The Japa- nese Journal of Physiology. – 1987. – V.37. – P.59– 79.

Sawanobori T., Adaniya H., Hirano Y., Hiraoka M. Effects of antiarrhythmic agents and Mg 2+ on aconitine–induced arrhythmias // Jpn. Heart. J. – 1996. – V.37. – P.709–718.

Watano T., Harada Y., Harada K., Nishimura N. Effect of Na + /Ca 2+ –exchange inhibitor, KB–R7943 on ouabain–induced arrhythmias in guinea–pigs // Br. J. Pharmacol. – 1999. – V.127. – P.1846–1850.

Lu H.R., Clerck D.F. R56865, a Na + /Ca 2+ – overload inhibitor, protects against aconitine induced cardiac arrhythmias in vivo // J. Cardiovasc. Pharmacol. – 1993. – V.22. – P.120–125.

Litwin S.E., Li J., Bridge J.B. Na-Ca exchange and the trigger for sarcoplasmic reticulum Ca release: studies in adult rabbit ventricular myocytes // Biophys. J. – 1998. – V.75. – Р.359–371.