P. A., 20 year-old white male, was admitted to Tashkent region’s hospital of skin and venereal diseases with a 9 month history of infiltrated, hyperemia with scaled and brownish color crusts, mild itching.[1] Physical examination revealed erythroderma, scaling with Powderly consistency, and additional findings scarring such Alopecia Areata. Scales are larger on extensor surface and lower extremities. The palms and soles are severely affected with diffuse fissuring keratoderma. Erythematous and crusting lesions on the head, face, neck, trunk, upper and lower extremities, genital area, more over changes of the nails: thickening and become brown. Laboratory examines show anemia and cultural investigation presents CandidaAlbicans andT.ectotrix. It was noticed paronichia.[3] On the 3 rd day of topicalkeratolytic (boric acid ointment 5%), antifungal therapy and oral diflucane all crusts was removed. The skin under the crusts was erythematous, withlaxity, and thin. No itching and pain.[2]