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ЭРКАКЛАРДА КОНТРИКАЛ ТАЪСИРИДА ФЕРТИЛЛИКНИНГ БУЗИЛИШИ БИЛАН СПЕРМАНИНГ ПРОТЕОЛИТИК ФАОЛЛИГИ ВА ИММУН ХУСУСИЯТЛАРИ ЎЗГАРИШИ

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MAQOLA ANNOTATSIYASI

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Эркакларда фертилликнинг ҳар хил бузилиши даражаси билан контрикал билан даволанишдан олдин ва кейин сперманинг потеолитик ҳамда антипротеолитик фаоллиги, интерлейкин, TGF-β ўрганилди. Тадқиқот натижаларидан қуйидаги хулосага келинди, контрикалнинг эркаклар спермасини иммун коррекция қилувчи сифатида қўлланиши унинг иммун тавсифини яхшилаш, шунингдек, сперманинг антипротеолитик фаоллигининг пасайиши ҳамда протеолитик фаоллигининг ошишига сабаб бўлади. Бундай ўзгаришлар сперманинг фертил хусусиятини яхшилайди

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# контрикал# сперма иммунитетлари# туғилишнинг салбийлиги# интерлеукин ҳолати# ТГФ-β# сперма протеолитик фаоллиги# sperm immune properties# impaired fertility# interleukin status# TGF-β# contrical# sperm proteolytic activity

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Foydalanilgan adabiyotlar

1. Desser L. et al. Oral therapy with proteolytic enzymes decreases excessive TGF-β levels in human blood //Cancer chemotherapy and pharmacology. – 2001. – Т. 47. – №. 1. – С. S10-S15. 2. Johansson M. et al. Semen activates the female immune response during early pregnancy in mice //Immunology. – 2004. – Т. 112. – №. 2. – С. 290-300. 3. Jones R. L. et al. TGF-β superfamily expression and actions in the endometrium and placenta //Reproduction. – 2006. – Т. 132. – №. 2. – С. 217-232. 4. Krol J., Kowalski R., Demska-Zakęś K., Hliwa P., Glogowski J. Proteolytic and anti-proteolytic activity in the seminal plasma of Eurasian perch (PercafluviatilisL.) during the spawning period. Czech J. Anim. Sci., 2011, vol. 56, no9, 390–397. 5. Kubiczkova L. et al. TGF-β–an excellent servant but a bad master //Journal of translational medicine. – 2012. – Т. 10. – №. 1. – С. 183. 6. Lauer D. et al. Modulation of growth factor binding properties of a2-macroglobulin by enzyme therapy //Cancer chemotherapy and pharmacology. – 2001. – Т. 47. – №. 1. – С. S4-S9. 7. McCaffrey T. A. et al. Transforming growth factor-beta activity is potentiated by heparin via dissociation of the transforming growth factor-beta/alpha 2-macroglobulin inactive complex //The Journal of Cell Biology. – 1989. – Т. 109. – №. 1. – С. 441-448. 8. Nelson S. M., Greer I. A. The potential role of heparin in assisted conception //Human Reproduction Update. – 2008. – Т. 14. – №. 6. – С. 623-645. 9. Robertson S. A. Seminal plasma and male factor signalling in the female reproductive tract //Cell and tissue research. – 2005. – Т. 322. – №. 1. – С. 43-52. 10. Sadat Z., Kalahroudi M. A., Saberi F. The effect of short duration sperm exposure on development of preeclampsia in primigravid women //Iranian Red Crescent Medical Journal. – 2012. – Т. 14. – №. 1. – С. 20. 11. Shadmanov A., Aleynik V., Babich S. at all. Therapeutic effects on performance wobenzymproteolytic and antiproteolitic activity in men with sperm impaired fertility. European applied sciences, Stuttgart, Germany, 2014, no 3, 47-48. 12. Yang L., Pang Y., Moses H. L. TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression //Trends in immunology. – 2010. – Т. 31. – №. 6. – С. 220-227.

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