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ALTERATION IN THE CONVULSIVE EFFECT OF KYNURENINE, CORAZOL AND CAFFEINE UNDER THE ACTION OF BICUCULLINE

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Scientific Bulletin of Namangan State University

Scientific Bulletin of Namangan State University

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ARTICLE ANNOTATION

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In male mice of two strains SHR and C57BL/6, pretreatment with bicuculline (1 mg/kg, s.c.), an antagonist of GABA-A receptors,potentially the convulsant effect of pentylenetetrazole (40mg/kg,ip.) and caffeine (200mg/kg ip.) and had no effect on that of L- kynurenine (11 meg i.c.v.).Data suggest that the convulsant effect of L-kynurenine, an endogenous convulsant from neuroactive tryptophan metabolites, is not related to GABA-A receptors. Other data reported elsewhere (e.g.the antagonism of phenibut and baclofen, agonists of GABA-B receptors, to L-kynurenine) suggest that kynurenine-induced seizures are related to GABA-B receptors.

AUTHORS

S.Mirzayev

B.Niyazmetov

Tags

# кинуренин# convulsive effect# bicuculline# corazol# kinurenin# GABA-A-B receptors# судорожный эффект# бикукуллин# коразол# рецепторы ГАМК-А-В# конвульсив таъсир# GABA-AB рецепторлари

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Article Identifiers

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https://eroi.uz/11.0031/A0121-0005

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Not Available

References

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Lapin I.P.Farmakologicheskiye razlichiya mezhdu kinureninovymi i korazolovymi sudorogami (uchastiye GAMK-B retseptorov i dofamina).-Eksper.i klinich.farmakol.-1998. -№ 2.С.20-22.

Dede F,Karadenizli S,ozsoy oD, Eraldemir FC, Şahin D,Ates N. The Effects of Adenosinergic Modulation on Cytokine Levels in a Pentylenetetrazole-Induced Generalized Tonic-Clonic Seizure Model. Neuroimmunomodulation. 2017;24(1):54-59.

Souza MA, Mota BC, Gerbatin RR,Rodrigues FS,Castro M, Fighera MR, Royes LF. Antioxidant activity elicited by low dose of caffeine attenuates pentylenetetrazol-induced seizures and oxidative damage in rat. J Basic Clin Physiol Pharmacol. 2018 Jan 26;29(1):110