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THE PREDICTION OF DEVELOPMENT OF GESTATIONAL TROPHOBLASTIC NEOPLASIA

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This study evaluated the expression of the CLIC-1 protein by immunohistochemical method in gestational trophoblastic disease, as well as its diagnostic value in predicting the malignant process. The study included 20 patients with gestational trophoblastic disease. There were higher levels of CLIC-1 immunoreactivity in trophoblastic cells in patients with gestational trophoblastic neoplasia compared with patients with hydatidiform mole. The level of CLIC-1 activity increases in malignantly transformed choriocarcinoma cells and is expressed in the nucleus and cytoplasm of trophoblastic cells. Thus, CLIC-1 can serve as a prognostic marker that allows detecting malignant transformation at an early stage

AUTHORS

M.Mamatova

Андижанский Государственный медицинский институт

D.Nadjmitdinova

Андижанский Государственный медицинский институт

Tags

# пузырный занос# гестационная трофобластическая б# хориокарцинома# иммуногистохимия# gestational trophoblastic diseas# hydatidiform mole# choriocarcinoma# immunohistochemistry# gestatsion trofoblastik kasallig# yelbo'g'oz# horiokarsinoma# immunogistokimyo

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Article Identifiers

ROI:

https://eroi.uz/11.0082/A1221-0002

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Not Available

References

2. Behtash N, Hasanzadeh M, Hanjani P. Complete remission of an unusual location of metastatic GTN: A case report. Cancer Ther 2005; 2: 575–577.

3. Makovitzky J, Radtke A, Shabani N, Friese K, Gerber B, Mylonas I. Invasive hydatidiform mole: Immunohistochemical labelling of inhibin/activin subunits, Ki67, p53 and glycodelin A in a rare case. Acta Histochem 2009; 111:360–365

1. Berek JS. Berek & Novak’s Gynecology, 14th edn. Philadelphia, PA: Lippincott Williams & Wilkins, 2007; 37: 1582–1604.

4. Xue WC, Khoo US, Ngan HY et al. Minichromosome maintenance protein 7 expression in gestational trophoblastic disease: Correlation with Ki67, PCNA and clinicopathological parameters. Histopathology 2003; 43: 485–490.

5. . FIGO Oncology Committee. FIGO staging for gestational trophoblastic neoplasia 2000. Int J Gynecol Obstet 2002; 77: 285–287.

6. Menczer J, Schreiber L, Berger E, Golan A, Levy T. Assessment of Her-2/neu expression in hydatidiform moles for predic

7. Soper JT. Staging and evaluation of gestational trophoblastic disease. Clin Obstet Gynecol 2003; 46: 570–578. 8. Yazaki-Sun S, D

8. Yazaki-Sun S, Daher S, de Souza Ishigai MM, Alves MT, Mantovani TM, Mattar R. Correlation of c-erbB-2 oncogene and p53 tumor suppressor gene with malignant transformation of hydatidiform mole. J Obstet Gynaecol Res 2006; 32: 265–272.

9. Friedli M, Guipponi M, Bertrand S, et al. Identification of a novel member of the CLIC family, CLIC6, mapping to 21q22.12. Gene. 2003;320:31Y40.

10. Chen CD, Wang CS, Huang YH, et al. Overexpression of CLCI1 in human gastric carcinoma and its clinicopathological significance. Proteomics. 2007;7:155Y167.