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VASORELAXANT STRUCTURALLY DEPENDENT EFFECT OF ALKALOIDS COPSININE AND N4-IODINE COPSININE METHYLATE

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Scientific Bulletin of Namangan State University

Scientific Bulletin of Namangan State University

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ARTICLE ANNOTATION

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In the research it was examined the vasorelaxant effect associated with the chemical structures of the alkaloids - copsinin and its derivative N4-iodine methylate copsinine, isolated from the aerial parts of Vinca erecta plant on the contractile activity of the rat aortic smooth muscle. In the experiments, the vasorelaxant effect of copsinin and its derivative N4-iodine methylate copsinine is associated with the concentration and chemical structure, and a relationship with Са2+L-channel blockade in the plasmalemma of smooth muscle blood cells.

AUTHORS

A.Zaynabiddinov

Андижон давлат университети

L.Yunusov

Андижон давлат университети

P.Usmanov

УзМУ хузуридаги биофизика ва биокимё интитути

SH.Adizov

ЎзР ФА акад. С. Юнусов ноимидаги Ўсимлик моддалари кимёси институти

E.Khalilov

Андижон давлат университети

F.Axmedov

Андижон давлат университети

A.Mutalipov

Андижон давлат университети

Tags

# алкалоид# қон томир# Са2+L-channel# alkaloids# копсинин# N4-йод метилат копсинин# силлиқ мускул# Са2+L–канали# вазорелаксант# N4-иод метилат копсинин# кровеносный сосуд# гладкая мышца# Са2+L–каналов# вазорелаксантный# copsinin# N4-iodine methylate copsinine# blood vessel# smooth muscle# vasorelaxant

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Article Identifiers

ROI:

https://eroi.uz/11.0031/A0722-0016

DOI:

Not Available

References

Adizov Sh.M.,Tashkhodzhaev., Pratik P., Upadhyay P.Kh., Yuldashev M., Mirzaeva M. Alkyl-and Acyl-Derivatives of Copsinine and Pseudocopsinine and Their Criystal Structures // Chemistry of Natural Compounds. – 2018. – V.54. – P.147-152.

Sadritdinov F.S., Kurmukov A.G. The Pharmacology of the Plant Alkaloids and Their Use in Medicine // Tashkent – 1980. – P.47.

Kim B., Jo C., Choi H.–Y., Lee K. Vasorelaxant and hypotensive effects of cheonwangbosimdan in SD and SHR rats // Hindawi Evidence–Based Complementary and Alternative Medicine. – 2018. – V.2018. – P.1–8.

Ozaki H., Ohyama T., Sato K., Karaki H. Ca2+–Dependent and independent mechanisms of sustained contraction in vascular smooth muscle of rat aorta // Japan J. Parmacol. – 1990. – V.52(510). – P.509–512.

Martinsen A., Baccelli C., Navarro I., Abad A., Quetin–Leclerc J., Morel N. Vascular activity of a natural diterpene isolated from Croton zambesicus and of a structurally similar synthetic trachylobane // Vascular Pharmacology. – 2010. – V.52. – P.63–69.