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SYNTHESIS OF THE BETULINIC ACID

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Scientific Reports of Fergana State University

Scientific Reports of Fergana State University

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ARTICLE ANNOTATION

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Today, one of the most important tasks for the further development of the pharmaceutical industry is medicines obtained from local raw materials. This article describes the production of betulin from the bark of the Betula pendula tree growing in the territory of Uzbekistan, the synthesis of various derivatives based on it, and the study of the structure of substances by physical methods. Based on these studies, medicines will be created from local raw materials.

AUTHORS

A.Xayitbayev

Fergana State University

SH.Turg'unboyev

Fergana State University

Tags

# экстракция# extraction# IR-spectroscopy# ИКспектроскопия# бетулин# betulin# Betula pendula# бетулон кислота# Джонс реактиви# гаултерин# фитостерин# бетулоновая кислота# реактив Джонса# betulonic acid# Jones reagent# gaulterine# phitosterine

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Article Identifiers

ROI:

https://eroi.uz/11.0106/A0822-0795

DOI:

Not Available

References

1. Толстиков Г.А., Флехтер О.Б., Шулц Э.Э., Балтина Л.А., Толстиков А.Г. Бетулин и его производные. Химия и биологическая активность. Химия в интересах устойчивого развития. 13. 2005.

2. Кузнецов Б.Н., Левданский В.А., Еськин А.П., Полежаева Н.И. Выделение бетулина и суберина из коры березы, активированной в условиях “взрывного автогидролиза”. Химия растительного сыря. 1998. № 1.

3. Zuco, V.; Supino, R.; Righetti, S. C.; Cleris, L.; Marchesi, E.; Gambacorti-Passerini, C.;Formelli, F. Selective cytotoxicity of betulinic acid tumor cell lines, but not on normal cells.Cancer Lett. 2002.

4. Pisha E.; Chai H.; Lee I.S.; Chagwedera T.E.; Farnsworth N.R.; Cordell G.A.; Beecher C.W.; Fong H.H.; Kinghorn A.D.; Brown D.M.; et al. Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis. Nat. Med.1995.

5. Fulda, S.; Jeremias, I.; Steiner, H. H.; Pietsch, T.; Debatin, K. M. Betulinic acid: a new cytotoxic agent against malignant brain-tumor cells. Int. J. Cancer 1999, 82, 435-441. Int. J. Mol. Sci. 2008.