METABOLIC ENGINEERING OF ARTEMISININ

Artemisinin in combination with other drugs is used to treat the parasite of malaria, one of the most dangerous parasitic diseases in the world. Due to the very low content of artemisin (~ 0.5-1.2%) in A. annua, it does not satisfy the need for artemisin. Methods of metabolic engineering and genetic engineering are used for microorganisms, Artemisia annua and other plants to solve this problem. This review provides information on the metabolic pathways of artemisinin biosynthesis in any gene involved that have been studied in recent years. By metabolic injection, it can obtain large amounts of artemisinin from Artemisia annua and other plants. This will decrease the price of artemisinin in the future and brings tremendous benefits to millions of people around the world.