DEVELOPMENT AND VALIDATION OF THE METHOD OF MASS SPECTROSCOPY IN THE ANALYSIS OF THE DRUG "INTRALIN"

In the pharmaceutical industry, medicines from the cephalosporin group have recently been widely produced. Features of cephalosporins include a wide spectrum of action, high bactericidal activity, relatively high resistance to beta-lactamases in comparison with penicillins. Cephalosporins have bactericidal properties and cause cell lysis. One of the widely available drugs in our Republic containing cefazolin is "Intralin" - a powder for the preparation of a solution for injections. For the standardization of the drug, valid validated methods of analysis are required that meet all the requirements. A technique for the analysis of the preparation "Intralin" was developed using the method of high-performance liquid chromatography-mass spectroscopy. Interpretation of mass-spectrometric fragmentation of cefazolin was carried out. Also, the developed methodology is validated for all parameters corresponding to the requirements of standardization.