logo
calendar21 Oktabr 2019
view39
Main language:Russian

STUDY OF POSSIBLE POLYMORPHISM IN CEFTRIAXONE PREPARATIONS OF DIFFERENT ORIGIN

Field of Science:
pdf

20191021093029_Farmvest....pdf

PDF

Oʻzbekiston farmatsevtik xabarnomasi

Oʻzbekiston farmatsevtik xabarnomasi

Publish Articlesee more

ARTICLE ANNOTATION

quote
Ceftriaxone disodium’s powder for preparation of injection solutions from 9 manufacturers selected on Uzbekistan pharmaceutical market examined for Z- and E-isomers content. It is shown, that testing of ceftriaxone impurities and probably polymorphism is possible using traditional RP- and chiral HPLC. Content of impurities and Е-isomer in tested samples were admissible, and therefore cannot be cause of drug polymorphism and subsequent significant difference in pharmaceutical efficacy

AUTHORS

A.Dusmatov

“ДВТТТБЭСДМ” ДУК

I.Maxmudova

“ДВТТТБЭСДМ” ДУК

Tags

# цефтриаксоннинг Z ва E изомерлар# ҚФ-ЮССХ# хирал хроматография# Z- и E-изомеры цефтриаксона# ОФ-ВЭЖХ# хиралная хроматография# ceftriaxone Z- and E-isomers# RP- and chiral HPLC

OTHER ARTICLES IN THIS JOURNAL

Rate Article

0
0 ratings
5
4
3
2
1

Article Identifiers

ROI:

https://eroi.uz/11.0014/A1019-0039

DOI:

Not Available

References

1. Zhang J., Qian J., Tong J., Zhang D., Hu C. Toxic Effects of Cephalosporins with Specific Functional Groups as Indicated by Zebrafish Embryo Toxicity Testing // Chem. Res. Toxicol., - 2013, 26 (8), - P. 1168-1181.

2. Ceftriaxone Sodium // British pharmacopoeia, Vol. 1, - P. 281-283.

3. Мащеноко З.Е., Шафигулин Р.В., Шаталаев И.Ф. Биодеградация цефтриаксона в процессе биологической очистки сточных вод // Известия Самарского научного центра РАН. - 2011. Т.13, №1(8), - С. 2070-2072.

4. Шафигулин Р.В., Мащенко З.Е., Буланова А.В., Шаталаев И.Ф. Хроматографический анализ цефтриаксона в модельных гидроэкосистемах // Сорбционные и хроматографические процессы. - 2013. Т. 13, Вып.1, - С. 75-82.

5. Rajadurai R., Sivakumar B., Murugan R., Anantham S., Naidu P.Y. Identification of E and Z isomers od some cephalosporins by NMR // Analyt. Chem. An Indian Journal. - 2010, 9(2), - P. 265-269.

6. Johnson J.E., Morales N.M., Gorczyca F.V., Dolliver D.D., McAllister M.A. Mechanisms of AcidCatalyzed Z/E Isomerization of Imines//J.Org.Chem., 2001, 66(24), P.7979-7985. DOI: 10.1021/jo010067k.