PRECLINICAL TOXICOLOGICAL STUDY OF "LESBOKHOL" - A MIXTURE OF DRY EXTRACTS FROM LOCAL FLORA

The study was conducted on mature mice, rats and rabbits of both genders. It has been established that the dry extract "Lesbokhol" from medicinal plants of the flora of Uzbekistan, at single intragastric (per os) administration in doses 10000 mg / kg does not cause lethality (VI class of toxicity according to OECD classification)in all animal species. In chronic (60-day) administration of the preparation, there were no statistically significant differences in weight, hematological and biochemical blood parameters between animals receiving ‘Lesbokhol’ and control animals receiving drinking water. "Lesbohol" did not cause pathological changes in internal organs and tissues, and also did not have a local irritant and allergic effect.