logo
calendar11 Aprel 2025
view31
Main language:English

ETIOPATHOGENETIC CHARACTERISTICS AND NEUROINFLAMMATORY NATURE OF KANNER SYNDROME IN CHILDREN

Field of Science:
pdf

67f93defb77a3.pdf

PDF

Eurasian Journal of Medical and Natural Sciences

Eurasian Journal of Medical and Natural Sciences

Publish Articlesee more

ARTICLE ANNOTATION

quote
Kanner syndrome is one of the most challenging forms of early-onset autism spectrum disorder (ASD), often associated with immune system dysregulation. In thisstudy, 60 children with Kanner syndrome and 30 healthy controls aged 3 to 6 years were examined using clinical, immunological, and biochemical methods. The correct assessment of immune-inflammatory status, including elevated cytokine levels and altered lymphocyte profiles, allowed for a deeper understanding of the disease pathogenesis. The study highlights the importance of immune biomarkers in early diagnosis, risk stratification, and development of personalized therapeutic strategies in neurodevelopmental disorders

AUTHORS

N.Khaydarov

Tashkent State Dental Institute,

F.Doniyorova

Tashkent State Dental Institute

M.Temirova

Tashkent Pediatric Medical Institute, Uzbekistan

Tags

# cytokines# Neuroinflammation# Kanner syndrome# autism spectrum disorder# immune biomarkers# early childhood

OTHER ARTICLES IN THIS JOURNAL

Rate Article

0
0 ratings
5
4
3
2
1

Article Identifiers

ROI:

https://eroi.uz/11.0201/A0425-0073

DOI:

Not Available

References

1.Baio J. et al. Prevalence of Autism Spectrum Disorder among Children Aged 8 Years —Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2014. MMWR Surveill Summ. 2018;67(6):1–23.2.Lord C. et al. Autism spectrum disorder. Lancet. 2020;392(10146):508–520.3.OnoreC., Careaga M., Ashwood P. The role of immune dysfunction in the pathophysiology of autism. Brain Behav Immun. 2012;26(3):383–392.4.Ashwood P., Krakowiak P., Hertz-Picciotto I., Hansen R., Pessah I.N., Van de Water J. Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome. Brain Behav Immun. 2011;25(1):40–45.5.Ministry of Health of the Republic of Uzbekistan. Annual Report on Pediatric Neurological Disorders, 2023.6.Vargas D.L., Nascimbene C., Krishnan C., Zimmerman A.W., Pardo C.A. Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann Neurol. 2005;57(1):67–81.7.Meltzer A., Van de Water J. The Role of the Immune System in Autism Spectrum Disorder. Neuropsychopharmacology. 2017;42(1):284–298.