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calendar3 Dekabr 2019
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PILOT STUDY OF GADOLINIUM ACCUMULATION IN GLIAL TUMORS OF HUMAN BRAIN

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The aim of our pilot clinical study was direct determination of gadolinium accumulation in glial tumors of human brain after single intravenous administration of Magnevist. Study was carried out on samples of glial tumors of human brain extracted during standard brain surgery.Samples from five patients with glial tumors and single intravenous administration of Magnevist in different times before surgery were studied. Samples of two patients with glial tumors and without intravenous administration of Magnevist and other gadolinium containing compounds were studied as control. Gadolinium content in tumor tissues was analyzed by method of neutron activation analysis. It was found that in all five investigated samples gadolinium present in concentrations from 0.0093 to 0.2384 ng/mg (ppm) tumor tissue. In control samples, the gadolinium has not been detected. At present time, the clinical importance of detected effect of gadolinium accumulation in brain tumors after intravenous introduction of pharmacological chelate compounds of gadolinium is not clear enough. As free gadolinium is toxic, so the establishment of fact of gadolinium accumulation in brain tumors can appear significant for interpretation of various unexpected clinical effects in the future

AUTHORS

I.Mavlyanov

RSTIAM

G.Kulabdullaev

RSTIAM

A.Kim

RSTIAM

G.Djurayeva

RSTIAM

S.Saitdjanov

RSTIAM

I.Sadikov

RSTIAM

B.Yarmatov

RSTIAM

A.Salimov

RSTIAM

R.Kadyrbekov

RSTIAM

D.Alimov

RSTIAM

N.Kadyrbekov

RSTIAM

Tags

# клиническое исследование# магневист# накопление гадолиния# опухоли головного мозга человека# нейтронно-активационный анализ# klinik tadqiqotlar# magnovist# gadoliniy birikmasi# inson miya shishi# neytron faollashuvi tahlillari# neytronni terapiya# clinical study# Magnevist# gadolinium accumulation# human brain glial tumors# neutron activation analysis# neutron-capture therapy# нейтронно-захватная терапия

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