EXPLOITING ENDOPHYTIC FUNGI FROM MEDICINAL PLANTS FOR NEW ANTIMICROBIAL AGENTS AGAINST RESISTANT PATHOGENS

1.World Health Organization. 10 global health issues to track in 2021. 2020. Available from: https://www.who.int/news-room/spotlight/10-global-health-issues-to-track-in-2021 [Accessed June 11, 2023].2.Strobel, G., & Daisy, B. (2003). Bioprospecting for microbial endophytes and their natural products. Microbiology and molecular biology reviews, 67(4), 491-502.3.Gouda, S., Das, G., Sen, S. K., Shin, H. S., & Patra, J. K. (2016). Endophytes: a treasure house of bioactive compounds of medicinal importance. Frontiers in microbiology, 7, 1538.4.Wijesekara T, Xu B. Health-Promoting Effects of Bioactive Compounds from Plant Endophytic Fungi. J Fungi (Basel). 2023 Oct 8;9(10):997. doi: 10.3390/jof9100997. PMID: 37888253; PMCID: PMC10608072.5.Alam B, Lǐ J, Gě Q, Khan MA, Gōng J, Mehmood S, Yuán Y, Gǒng W. Endophytic Fungi: From Symbiosis to Secondary Metabolite Communications or Vice Versa? Front Plant Sci. 2021 Dec 17;12:791033. doi: 10.3389/fpls.2021.791033. PMID: 34975976; PMCID: PMC8718612.6.Michael CA, Dominey-Howes D, Labbate M. The antibiotic resistance crisis: causes, consequences, and management. Front Public Health. 2014;2:1457.El-Deeb, B., Fayez, K., & Gherbawy, Y. (2012). Isolation and characterization of endophytic bacteria from Plectranthus tenuiflorus medicinal plant in Saudi Arabia desert and their antimicrobial activities. Journal of Plant Interactions, 8(1), 56–64. https://doi.org/10.1080/17429145.2012.6800778.Jalali A, Dabaghian F, Zarshenas MM. Alkaloids of Peganum harmala: Anticancer Biomarkers with Promising Outcomes. Curr Pharm Des. 2021;27(2):185-196. doi: 10.2174/1381612826666201125103941. Published November 25, 2020.9.Kajbaf, Forough, et al. "Assessment of the Anti-apoptotic Effects of Peganum harmala Leaf Extract on Type 2 Diabetes in the Kidney of Male Wistar Rats." Avicenna Journal of Medical Biochemistry 8.2 (2020): 74-82.10.Piechowska P, Zawirska-Wojtasiak R, Mildner-Szkudlarz S. Bioactive β-Carbolines in Food: A Review. Nutrients. 2019 Apr 11;11(4):814. doi: 10.3390/nu11040814. PMID: 30978920; PMCID: PMC6520841.11.Bakhodir Mamarasulov, Kakhramon Davranov and Dilfuza Jabborova (2020). Phytochemical, pharmacological and biological properties of Ajuga turkestanica (Rgl.) Brig (Lamiaceae). Ann. Phytomed., 9(1):44-57. http://dx.doi.org/ 10.21276/ap.2020.9.1.612.Cheng, D.M., Yousef, G.G., Grace, M.H. In vitro production of metabolic enhancing phytoecdysteroids from Ajuga turkestanica. Plant Cell Organ Cult 93, 73–83 (2008).13.Syrov, V.N., Yuldasheva, N.Kh., Egamova, F.R., et al., Assessment of hypoglycemic action of phytoecdysteroids, Exp. Clin. Pharmacol., 2012, vol. 75, no. 5, pp. 28–31.14.Iranshahi M, Masullo M, Asili A, et al. Sesquiterpene coumarins from Ferula gumosa. J. Nat Prod. 2010;73(11):1958-1962. doi: 10.1021/np100487j15.Yao D, Pan D, Zhen Yu et al. Ferulin C induces potent antitumor effects of PAK1 and p21 in breast cancer by inhibiting tubulin polymerization in vitro and in vivo. Pharmacol Res. 2020;152:104605. doi:10.1016/j.phrs.2019.104605.