logo
calendar3 Yanvar 2020
view27
Main language:Russian

STATE OF THE CARDIOVASCULAR SYSTEM IN PATIENTS WITH ITSENKO-CUSHING DISEASE

Field of Science:
pdf

file.pdf

PDF

Биомедицина ва амалиёт журнали

Биомедицина ва амалиёт журнали

Publish Articlesee more

ARTICLE ANNOTATION

quote
We examined 20 patients aged 20 to 62 years who underwent transnasal adenomectomy and radiation therapy for corticotropin. Some patients after surgery and radiation therapy were treated with ketoconazole at a dose of 400-600 mg / day. Blood pressure was determined for all patients, body mass index was calculated, basal levels of adrenocorticotropic hormone and cortisol, daily rhythm of and cortisol were determined, electrocardiography and transthoracic echocardiography were performed. According to the levels of adrenocorticotropic, cortisol and the daily rhythm of both hormones, 70% of the examined patients were in a state of decompensation. The average body mass index of the examined patients corresponded to II degree obesity. Moreover, in patients with an active stage of the disease, body mass index was significantly higher than in patients in the phase of drug remission. Arterial hypertension occurred in 95 % of patients with NIB. Most of the patients (14/70%) had I, the rest (6/30%) had II degree of hypertension (according to WHO classification, 1999).

AUTHORS

A.Dosanova

Қозоғистон тиббиий узулуксиз таълим университети

R.Bazarbekova

Қозоғистон тиббиий узулуксиз таълим университети

Tags

# сердечно-сосудистая система# cardiovascular system# юрак қон-томир тизими# болезнь Иценко-Кушинга# концентрическая гипертрофия миок# Иценко – Кушинг касаллиги# миокарднинг концентрик гипертроф# Itsenko-Cushing’s disease# concentric myocardial hypertroph

OTHER ARTICLES IN THIS JOURNAL

Rate Article

0
0 ratings
5
4
3
2
1

Article Identifiers

ROI:

https://eroi.uz/11.0037/A0120-0006

DOI:

Not Available

References

1. Gesmundo I , Miragoli M , Carullo P . et all. Growth hormonereleasing hormone attenuates cardiac hypertrophy and improves heart function in pressure overload-induced heart failure // Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):12033-12038. doi: 10.1073/pnas.1712612114. Epub 2017 Oct 25.

2. Tsai TC 1 , Shih CC 1,2 , Chien HP Anti-apoptotic effects of IGF-I on mortality and dysmorphogenesis in tbx5-deficient zebrafish embryos // BMC Dev Biol. 2018 Mar 5;18(1):5. doi: 10.1186/s12861-017-0161-1.

3 Ekhokardiografiya: mezhdunarodnye prakticheskie rukovodstva i rekomendacii.[ Echocardiography: international practical guidelines and recommendations] / A.Zh. Arystan, D.V. Fetcer, D.A. Osmonov, V.V. Benberin. Pod redakciej T.A. Batyralieva. – Bishkek: OsOO «Global Print», 2018 – 120 s

4. Mel’nichenko G.A., Popovich V., Rozhinskaya L.Ya., Belaya Zh.E. Medikamentoznaya terapiya bolezni Icenko-Kushinga. Sovremennoe sostoyanie problem [Drug therapy of Itsenko-Cushing’s disease. The current state of the problem] // Problemy endokrinologii. 2014;60(6): 29-37.

5 Belaya Zh.E., Rozhinskaya L.Ya., Dragunova N.V., Dzeranova L.K., Marova E.I., Arapova S.D., i dr. Metabolicheskie oslozhneniya endogennogo giperkorticizma. Vybor pacientov dlya skrininga [Metabolic complications of endogenous hypercorticism. Selection of patients for screening.]. // Ozhirenie i Metabolizm. - 2013. - №1. - S. 26-31. doi: 10.14341/2071-8713-5068

6. Mel’nichenko G.A., Dedov I.I. Klinicheskie rekomendacii Bolezn’ Icenko-Kushinga: Klinika, diagnostika, differencial’naya diagnostika, metody lecheniya. [Clinical recommendations ItsenkoCushing’s disease: Clinic, diagnosis, differential diagnosis, treatment methods.] -M., 2014.

7. Dedov I.I., Mel’nichenko G.A., Marova E.I., Arapova S.D., Belaya Zh.E., Rozhinskaya L.Ya., i dr. Bolezn’ Icenko-Kushinga: klinika, diagnostika, lechenie. [Itsenko-Cushing’s disease: clinic, diagnosis, treatment.] / Pod redakciej Dedova I.I., Mel’nichenko G.A. Prakticheskoe rukovodstvo dlya vrachej. - M.; 2012.

8 Marova E.I., Arapova S.D., Belaya Zh.E. i dr. Bolezn’ Icenko-Kushinga: klinika, diagnostika, lechenie. [Itsenko-Cushing’s disease: clinic, diagnosis, treatment.] M.: GEOTAR-Media, 2012; s. 64.

9 Mel’nichenko G.A., Dedov I.I. Klinicheskie rekomendacii Bolezn’ Icenko-Kushinga: Klinika, diagnostika, differencial’naya diagnostika, metody lecheniya. [Clinical recommendations ItsenkoCushing’s disease: Clinic, diagnosis, differential diagnosis, treatment methods.] -M., 2014.

10. Kirilyuk M.L. Bolezn’ Icenko-Kushinga. Sovremennye podhody k diagnostike i lecheniyu (klinicheskaya lekciya) [Modern approaches to diagnosis and treatment (clinical lecture) ] // Endokrinologiya: novosti, mneniya, obuchenie №1 2014. –S. 54- 67.

11 Dzeranova L.K., Pankratova Yu.V., Belaya Zh.E. i dr. Giperkorticizm i metabolicheskij sindrom: slozhnosti differencial’noj diagnostiki i lecheniya [Hypercorticism and metabolic syndrome: the difficulties of differential diagnosis and treatment ] // Ozhirenie i metabolizm 2- 2012- S. 57 -61.

12. Kovaleva Yu.A., Ilovajskaya I.A., Dreval’ A.V., Starostina E.G. Kardiorespiratornye narusheniya pri akromegalii [Cardiorespiratory disorders in acromegaly] // RMZh. 2016. No 1. S.19–24.

13. Mahamadaliev Ergash Yulchievich, Ul’trazvukovaya diagnostika i kliniko-biohimicheskie kriterii razvitiya paratonzillyarnogo abscessa.[ Ultrasonic diagnosis and clinical and biochemical criteria for the development of paratonsillar abscess] Journal of Biomedicine and Practice 2019, vol. 2, issue 3, pp.83-90 http:/10.26739/2181-9300-2019-3-9

14. Zhulidova A.Yu., Dubinina I.I. Akromegaliya i komorbidnye sostoyaniya. Novye vozmozhnosti diagnostiki i lecheniya (obzor literatury) [Acromegaly and comorbid conditions. New diagnostic and treatment options (literature review)]// Rossiskij medikobiologicheskij vestnik imeni akademika I.P. Pavlova. 2018. T. 26. №1. S. 117- 132. DOI: 10.23888/PAVLOVJ2018261117-132

15. Feelders RA, Pulgar SJ, Kempel A, Pereira AM. MANAGEMENT OF ENDOCRINE DISEASE: The burden of Cushing’s disease: clinical and health-related quality of life aspects. European Journal of Endocrinology. 2012;167(3):311-326. doi: 10.1530/eje-11-1095