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SUPERCRITICAL EXTRACTION OF GLABRIDIN FROM GLYCYRRHIZA GLABRA SHELF OF PRODUCTION OF GLYCIRRIZIN ACID OR ITS SALTS

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"Pharmaceutical Journal"

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ARTICLE ANNOTATION

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The yield of glabridin flavonoid in the preparation of glycyrrhizic acid and its salts by extraction of licorice roots with various solvents was studied. As a result, it was found that when receiving glabridine by extracting the raw material with water at 60°C, the yield of glycyrrhizic acid and its salts is the smallest result - 4.4%. The dried meal obtained after extraction is selected as an object for further research. In supercritical extraction at a pressure of 100-270 bar, a temperature of 50°C and a time of 60-150 min also with different concentrations of a co-solvent - alcohol, the amount of glabridine in the CO2 extract was determined. As a result, the optimal conditions for the process were identifed: 80% alcohol as a cosolvent, pressure 250 bar, temperature 50°C and extraction time 120 min.

AUTHORS

A.Sanoyev

N.Mukarramov

R.Halilov

SH.Sagdullayev

Tags

# шрот# ширинмия илдизи# licorice root# meal# корни солодки# сорастворитель# глабридин# СО2–экстракт# сверхкритическая флюидная экстра# ҳамроҳ эритувчи# юқори критик флюид экстракция.# co-solvent# glabridin# CO2-extract# supercritical fluid extraction.

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https://eroi.uz/11.0035/A0420-0001

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References

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