459

  • Read count375
  • Date of publication29-01-2021
  • Main LanguageRus
  • Pages73-79
Tags
Ўзбек

Семенная  плазма включает  воспалительные и противовоспалительные факторы, такие как интерлейкины и их растворимые рецепторы,  цитокины,  простагландины,  рост трансформирующие факторы. Особенностью семенной плазмы является то, что содержание в ней некоторых цитокинов существенно превосходит сходные сывороточные показатели. Это указывает на возможное участие цитокинов в репродуктивной функции. 

English

The seminal plasma includes inflammatory and anti-inflammatory factors such as interleukins and their soluble receptors, cytokines, prostaglandins, growth transforming factors. A feature of seminal plasma is that the content of some cytokines in it significantly exceeds similar serum indicators. This indicates a possible involvement of cytokines in reproductive function. 

Ўзбек

Уруғ плазма таркибига ялиғланиш ва ялиғланишга қарши омиллар, масалан интерлейкинлар ва уларнинг эрувчан рецепторлари, цитокинлар, простагландинлар, ўсишни ўзгартирувчи омиллар киради. Уруғ  плазмасининг ўзига ҳос ҳусусияти шундаки, ундаги баъзи цитокинларнинг таркиби шунга ўҳшаш зардоб кўрсатгичларидан сезиларли даражада юкори.  Бу цитокинларнинг репродуктив функциясига таъсир қилиш эҳтимолини кўрсатади.  

№ Name of reference
1 1. Shigetomi, H., Onogi, A., Kajiwara, H., Yoshida, S., Furukawa, N., Haruta, S., ... & Oi, H. Anti-inflammatory actions of serine protease inhibitors containing the Kunitz domain //Inflammation research. – 2010. – Т. 59. – №. 9. – С. 679-687.
2 2. Sintsova, O. V., Monastyrnaya, M. M., Pislyagin, E. A., Menchinskaya, E. S., Leychenko, E. V., Aminin, D. L., & Kozlovskaya, E. P. Anti-inflammatory activity of a polypeptide from the Heteractis crispa sea anemone //Russian Journal of Bioorganic Chemistry. – 2015. – Т. 41. – №. 6. – С. 590-596.
3 3. Kobayashi, H., Yoshida, R., Kanada, Y., Fukuda, Y., Yagyu, T., Inagaki, K., ... & Terao, T. Dietary supplementation of soybean kunitz trypsin inhibitor reduces lipopolysaccharideinduced lethality in mouse model //Shock. – 2005. – Т. 23. – №. 5. – С. 441-447.
4 4. Kobayashi, H., Yoshida, R., Kanada, Y., Fukuda, Y., Yagyu, T., Inagaki, K., ... & Kitanaka, T. A soybean unitz trypsin inhibitor reduces tumor necrosis factor‐α production in ultraviolet‐exposed primary human keratinocytes //Experimental dermatology. – 2005. – Т. 14. – №. 10. – С. 765-774.
5 5. McCaffrey, T. A., Falcone, D. J., Vicente, D., Du, B., Consigli, S., & Borth, W. Protection of transforming growth factor β activity by heparin and fucoidan //Journal of cellular physiology. – 1994. – Т. 159. – №. 1. – С. 51-59.
6 6. Molor-Erdene P. et al. Urinary trypsin inhibitor reduces LPS-induced hypotension by suppressing tumor necrosis factor-α production through inhibition of Egr-1 expression //American Journal of Physiology-Heart and Circulatory Physiology. – 2005. – Т. 288. – №. 3. – С. H1265-H1271.
7 7. Cao, Y. Z., Tu, Y. Y., Chen, X., Wang, B. L., Zhong, Y. X., & Liu, M. H. Protective effect of Ulinastatin against murine models of sepsis: inhibition of TNF-α and IL-6 and augmentation of IL-10 and IL-13 //Experimental and Toxicologic Pathology. – 2012. – Т. 64. – №. 6. – С. 543-547.
8 8. Day, J. R., Taylor, K. M., Lidington, E. A., Mason, J. C., Haskard, D. O., Randi, A. M., & Landis, R. C. Aprotinin inhibits proinflammatory activation of endothelial cells by thrombin through the protease-activated receptor 1 //The Journal of Thoracic and Cardiovascular Surgery. – 2006. – Т. 131. – №. 1. – С. 1-27.
9 9. Landis R. C. Protease activated receptors: clinical relevance to hemostasis and inflammation //Hematology/oncology clinics of North America. – 2007. – Т. 21. – №. 1. – С. 103-113.
10 10. Harig, F., Feyrer, R., Mahmoud, F. O., Blum, U., & Von der Emde, J. Reducing the postpump syndrome by using heparin-coated circuits, steroids, or aprotinin //The Thoracic and cardiovascular surgeon. – 1999. – Т. 47. – №. 0 . – С. 111-118.
11 11. Baufreton C. et al. Heparin coating with aprotinin reduces blood activation during coronary artery operations //The Annals of thoracic surgery. – 1997. – Т. 63. – №. 1. – С. 50-56
12 12. Eggert-Kruse W. et al. Relationship of seminal plasma interleukin (IL)-8 and IL-6 with semen quality //Human reproduction. – 2001. – Т. 16. – №. 3. – С. 517-528.
13 13. Robertson, S.A., Guerin L.R., Bromfield J.J., Branson K.M., Ahlström A.C., Care A.S. Seminal fluid drives expansion of the CD4+ CD25+ T regulatory cell pool and induces tolerance to paternal alloantigens in mice. Biology of reproduction, 2009, 80(5), 10361045.
14 14. Kubiczkova L. et al. TGF-β–an excellent servant but a bad master //Journal of translational medicine. – 2012. – Т. 10. – №. 1. – С. 183.
15 15. Sadat Z., Kalahroudi M. A., Saberi F. The effect of short duration sperm exposure on development of preeclampsia in primigravid women //Iranian Red Crescent Medical Journal. – 2012. – Т. 14. – №. 1. – С. 20.
16 16. Yang L., Pang Y., Moses H. L. TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression //Trends in immunology. – 2010. – Т. 31. – №. 6. – С. 220-227.
Waiting