150

Шистосомоз человека остается важной проблемой для здоровья во многих тропических регионах. По меньшей мере 261 миллион человек нуждаются в лечении от шистосомоза, и до 659 миллионов человек находятся в группе риска. Шистосомоз женских половых органов (ФГС) в первую очередь является проявлением инфекции Schistosomahaematobium. Учитывая характер признаков и симптомов ФГС, женщины обращаются за медицинской помощью с симптомами бесплодия или заболеваний, передающихся половым путем. Врачи, как правило, не знают о ФГС, потому что в этих медицинских учебниках или программах для медсестер не описывается ни одна страна, где распространеншистосомоз. Лабораторной диагностики недостаточно.

  • Read count124
  • Date of publication30-01-2021
  • Main LanguageRus
  • PagesШИСТОСОМОЗ ЖЕНСКИХ ПОЛОВЫХ ОРГАНОВ
Русский

Шистосомоз человека остается важной проблемой для здоровья во многих тропических регионах. По меньшей мере 261 миллион человек нуждаются в лечении от шистосомоза, и до 659 миллионов человек находятся в группе риска. Шистосомоз женских половых органов (ФГС) в первую очередь является проявлением инфекции Schistosomahaematobium. Учитывая характер признаков и симптомов ФГС, женщины обращаются за медицинской помощью с симптомами бесплодия или заболеваний, передающихся половым путем. Врачи, как правило, не знают о ФГС, потому что в этих медицинских учебниках или программах для медсестер не описывается ни одна страна, где распространеншистосомоз. Лабораторной диагностики недостаточно.

Ўзбек

Odam shistosomozi ko'plab tropik mintaqalarda sog'liqni saqlashning muhim muammosi bo'lib qolmoqda. Kamida 261 million odam shistosomoz bilan davolanishga muhtoj va 659 milliongacha odam xavf ostida. Ayollarning jinsiy shistosomozi (FGS) asosan Schistosomahaematobium infektsiyasining namoyonidir. FGS belgilari va belgilarining xususiyatini hisobga olgan holda, ayollar tibbiy xizmatga bepushtlik yoki jinsiy yo'l bilan yuqadigan kasalliklar alomatlari bilan murojaat qilishadi. Shifokorlar odatda FGSni bilishmaydi, chunki bu tibbiyot darsliklari yoki hamshiralar o'quv dasturlarida shistosomoz tarqaladigan biron bir mamlakat tasvirlanmagan. Laboratoriya diagnostikasi yetarliemas.

English

Human schistosomiasis remains an important public health problem in many tropical settings. At least 261 million people require treatment for schistosomiasis and up to 659 million people are at risk. Female genital schistosomiasis (FGS) is a manifestation mainly of Schistosomahaematobium infection. Given the nature of the signs and symptoms of FGS, women tend to approach health services with complaints of infertility or symptoms of sexually transmitted infections. Clinicians are generally unaware of FGS because it is not described in the medical textbooks or nursing curricula in any of the countries where schistosomiasis is endemic. Laboratory diagnostics are inadequate.

Author name position Name of organisation
1 Turgunova D.Z. . ASMI
2 Xojimatova G.M. . ASMI
Name of reference
1 1. Gilbert B. Schistosomiasis (bilharziasis) of the female genital tract and neighbouring tissues. J ObstetGynaecol Br Emp. 1943;50(5):317–36.
2 2. Charlewood GP, Shippel S, Renton H. Schistosomiasis in gynaecology. J ObstetGynaecol Br Emp. 1949 Jun;56(3):367–85.
3 3. Bland KG, Gelfand M. The effects of schistosomiasis on the cervix uteri in the African female.J ObstetGynaecol Br Commonw. 1970 Dec;77(12):1127–31.
4 4. Gelfand M, Ross MD, Blair DM, Weber MC. Distribution and extent of schistosomiasis in female pelvic organs, with special reference to the genital tract, as determined at autopsy. Am J Trop Med Hyg. 1971 Nov;20(6):846–9.
5 5. Kjetland EF, Poggensee G, Helling-Giese G, Richter J, Sjaastad A, Chitsulo L, et al. Female genital schistosomiasis due to Schistosomahaematobium. Clinical and parasitological findings in women in rural Malawi.Acta Trop. 1996 Dec 30;62(4):239–55
6 6. Galappaththi-Arachchige HN, AmlieHegertun IE, Holmen S, Qvigstad E, Kleppa E, Sebitloane M, et al. Association of urogenital symptoms with history of water contact in young women in areas endemic for S. haematobium. A cross-sectional study in rural South Africa.Int J Environ Res Public Health. 2016 11 14;13(11):1135
7 7. Kjetland EF, Ndhlovu PD, Mduluza T, Gomo E, Gwanzura L, Mason PR, et al. Simple clinical manifestations of genital Schistosomahaematobium infection in rural Zimbabwean women. Am J Trop Med Hyg. 2005 Mar;72(3):311–9.
8 8. Hay SI, Abajobir AA, Abate KH, Abbafati C, Abbas KM, Abd-Allah F, et al.; GBD 2016 DALYs and HALE Collaborators. Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017 Sep 16;390(10100):1260–344.
9 9. Hotez PJ, Engels D, Gyapong M, Ducker C, Malecela MN.Female genital schistosomiasis. N Engl J Med. 2019 Dec 26;381(26):2493–5.
10 10. Dirk Engels,a Peter J Hotez,b Camilla Ducker,c Margaret Gyapong,d Amaya L Bustinduy,e William E Secor,f Wendy Harrison,c Sally Theobald,g Rachael Thomson,h Victoria Gamba,iMakia C Masong,j Patrick Lammie,kKreeneshniGovender,l Pamela S Mbabazim&Mwelecele N Malecelam. Integration of prevention and control measures for female genital schistosomiasis, HIV and cervical cancer. 2020 Sep 1; 98(9): 615–624
11 11. Chiappino-Pepe, A. et al. (2017) Bioenergetics-based modeling of Plasmodium falciparum metabolism reveals its essential genes, nutritional requirements, and thermodynamic bottlenecks. PLoSComput. Biol. 13, e1005397
12 12. Stothard, J. R., Odiere, M. R., & Phillips-Howard, P. A. (2020). Connecting Female Genital Schistosomiasis and Menstrual Hygiene Initiatives. Trends in Parasitology, 36(5), 410–412.
13 13. Sturt AS, Webb EL, Phiri C, Mweene T, Chola N, van Dam GJ, et al. Genital self-sampling compared with cervicovaginal lavage for the diagnosis of female genital schistosomiasis in Zambian women: the BILHIV Study. PLoSNegl Trop Dis. 2020; (Forthcoming).
14 14. Female genital schistosomiasis: opportunities for research [internet]. Global Schistosomiasis Alliance; 2019. Available from: https://www .eliminateschisto.org/news-events/events/female-genital-schistosomiasis -opportunities-for-research [cited 2020 Jun 16].
15 15. Savioli L, Albonico M, Engels D, Montresor A. Progress in the prevention and control of schistosomiasis and soil-transmitted helminthiasis. Parasitol Int. 2004 Jun;53(2):103–13.
16 16. Kayuni S, Lampiao F, Makaula P, Juziwelo L, Lacourse EJ, Reinhard-Rupp J, et al. A systematic review with epidemiological update of male genital schistosomiasis (MGS): a call for integrated case management across the health system in sub-Saharan Africa. Parasite Epidemiol Control. 2019;4:e00077
17 17. Richter J, Poggensee G, Kjetland EF, Helling-Giese G, Chitsulo L, Kumwenda N, et al. Reversibility of lower reproductive tract abnormalities in women with Schistosomahaematobium infection after treatment with praziquantel – an interim report. Acta Trop. 1996 Dec 30;62(4):289–301.
18 18. Kleppa E, Ramsuran V, Zulu S, Karlsen GH, Bere A, Passmore JA, et al. Effect of female genital schistosomiasis and anti-schistosomal treatment on monocytes, CD4+ T-cells and CCR5 expression in the female genital tract. PLoS One. 2014 06 4;9(6):e98593
19 19. Kjetland EF, Mduluza T, Ndhlovu PD, Gomo E, Gwanzura L, Midzi N, et al. Genital schistosomiasis in women: a clinical 12-month in vivo study following treatment with praziquantel. Trans R Soc Trop Med Hyg. 2006 Aug;100(8):740–52.
20 20. Temmerman M, Khosla R, Say L. Sexual and reproductive health and rights: a global development, health, and human rights priority. Lancet. 2014 Aug 2;384(9941):e30–1
21 21. Stoever K, Molyneux D, Hotez P, Fenwick A. HIV/AIDS, schistosomiasis, and girls. Lancet. 2009 Jun 13;373(9680):2025–6.
22 22. Female genital schistosomiasis: a pocket atlas for clinical health care professionals. Geneva: World Health Organization; 2015.
23 23. Langenberg MCC, Hoogerwerf MA, Koopman JPR, Janse JJ, Kos-van Oosterhoud J, Feijt C, et al. A controlled human Schistosomamansoni infection model to advance novel drugs, vaccines and diagnostics. Nature Medicine.
24 24. Cnops L, Huyse T, Maniewski U, Soentjens P, Bottieau E, van Esbroeck M, et al. Acute schistosomiasis with a Schistosomamattheei x S. haematobium hybrid species in a cluster of 34 travelers infected in South Africa. Clinical Infectious Diseases. 2020;
25 25. Kayuni SA, Corstjens P, LaCourse EJ, Bartlett KE, Fawcett J, Shaw A, et al. How can schistosome circulating antigen assays be best applied for diagnosing male genital schistosomiasis (MGS): an appraisal using exemplar MGS cases from a longitudinal cohort study among fishermen on the south shoreline of Lake Malawi. Parasitology. 2019;146(14):1785-95.
26 26. Hotez PJ, Engels D, Gyapong M, Ducker C, Malecela MN. Female genital schistosomiasis.New England Journal of Medicine. 2019;381(26):2493-5.
27 27. 27. Stothard, R., & Webster, B. L. (2020). Acute schistosomiasis: Which molecular diagnostic test is best and why.Clinical Infectious Diseases. doi:10.1093/cid/ciaa319
Waiting