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Acute infectious and inflammatory processes in the upper respiratory tract still form the main list of diseases in childhood, which maintains the constant interest in this pathology of specialists in various fields, such as pediatricians, infectious disease specialists, otorhinolaryngologists, allergists, and immunologists. Particular attention of researchers and clinicians is attracted by the study of the etiopathogenetic mechanisms of the occurrence of laryngotracheitis, which is caused, first of all, by the development of a life-threatening condition of acute stenosis of the respiratory tract in children. According to our observations and according to the literature, there has recently been a clear trend towards an increase in the frequency of repeated episodes of acute stenosing laryngotracheitis (ASLT) in children, which makes it obvious that further study of the underlying mechanisms of not only the occurrence, but also the recurrence of ASLT is necessary. Recurrence of laryngotracheitis contributes to the formation of chronic inflammatory processes and hyperreactivity of the upper respiratory tract, negatively affects the maturation of the child's immune system, which leads to the development of secondary immunosuppression. Each new respiratory infection provokes more and more serious disorders of the immune system, contributing to the formation of both chronic inflammatory diseases of the pharynx and respiratory allergies. The modern concept of the etiopathogenesis of laryngotracheitis takes into account the action of multiple infectious and allergic trigger factors, the most significant in immunocompromised children. Currently, the primary tasks awaiting solution are timely prevention and diagnosis, the provision of highly qualified medical care, including bronchopulmonary diseases in children by expanding the use of modern methods of diagnosis and treatment, which will improve the quality of life of children.

  • Read count 286
  • Date of publication 06-10-2022
  • Main LanguageIngliz
  • Pages25-31
English

Acute infectious and inflammatory processes in the upper respiratory tract still form the main list of diseases in childhood, which maintains the constant interest in this pathology of specialists in various fields, such as pediatricians, infectious disease specialists, otorhinolaryngologists, allergists, and immunologists. Particular attention of researchers and clinicians is attracted by the study of the etiopathogenetic mechanisms of the occurrence of laryngotracheitis, which is caused, first of all, by the development of a life-threatening condition of acute stenosis of the respiratory tract in children. According to our observations and according to the literature, there has recently been a clear trend towards an increase in the frequency of repeated episodes of acute stenosing laryngotracheitis (ASLT) in children, which makes it obvious that further study of the underlying mechanisms of not only the occurrence, but also the recurrence of ASLT is necessary. Recurrence of laryngotracheitis contributes to the formation of chronic inflammatory processes and hyperreactivity of the upper respiratory tract, negatively affects the maturation of the child's immune system, which leads to the development of secondary immunosuppression. Each new respiratory infection provokes more and more serious disorders of the immune system, contributing to the formation of both chronic inflammatory diseases of the pharynx and respiratory allergies. The modern concept of the etiopathogenesis of laryngotracheitis takes into account the action of multiple infectious and allergic trigger factors, the most significant in immunocompromised children. Currently, the primary tasks awaiting solution are timely prevention and diagnosis, the provision of highly qualified medical care, including bronchopulmonary diseases in children by expanding the use of modern methods of diagnosis and treatment, which will improve the quality of life of children.

Author name position Name of organisation
1 Uralov S.M. Candidate of Medical Sciences, Associate Professor Samarqand State Medical University
2 Aralov M.Z. Candidate of Medical Sciences, Associate Professor Samarqand State Medical University
3 Holikova G.A. Assistant of the Department Samarkand State Medical University
4 Najimov S.R. Assistant of the department Samarkand State Medical University
Name of reference
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