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In modern conditions, the competitiveness of drugs is determined not only by the direction of their action, relevance, but also by the level of quality, quality-price ratio. In creating conditions for the production of competitive solid dosage forms, in particular tablets, a scientifically based selection of high-quality excipients is essential. In the development and improvement of the production of modern solid dosage forms, the leading role is played by high-molecular compounds, which make it possible tocreate drugs with predictable biopharmaceutical and technological parameters. In domestic pharmaceutical production, a new generation of high-molecular auxiliary substances produced by foreign companies is increasingly being introduced

  • Read count 41
  • Date of publication 01-05-2024
  • Main LanguageIngliz
  • Pages188-198
English

In modern conditions, the competitiveness of drugs is determined not only by the direction of their action, relevance, but also by the level of quality, quality-price ratio. In creating conditions for the production of competitive solid dosage forms, in particular tablets, a scientifically based selection of high-quality excipients is essential. In the development and improvement of the production of modern solid dosage forms, the leading role is played by high-molecular compounds, which make it possible tocreate drugs with predictable biopharmaceutical and technological parameters. In domestic pharmaceutical production, a new generation of high-molecular auxiliary substances produced by foreign companies is increasingly being introduced

Author name position Name of organisation
1 Azimova N.A. ! !
2 Maksudova F.K. ! !
3 Dusmetova Z.R. ! !
4 Rakhimova G.. ! !
5 Rakhimova O.. ! !
Name of reference
1 1. Sheskey, PJ, Cook, WG, and Cable, CG, 2017, Handbook of Pharmaceutical Excipients, Pharmaceutical Press, The Royal Phramaceutical Society of Great Britain, p. 138-152; 505-527.2. GK Bolhuis and ZT Chowhan, “Materials for direct compaction,” Pharmaceutical Powder Compaction Technology (ed. Alderborn G, Nyström C), Marcel Dekker, New York, 2013, pages 419-478.3. W. Zebrowska and W. Sawicki, “Excipients,” The applied pharmacy (ed. S. Janicki, A. Fiebig, M. Sznitowska), PZWL, Warsaw 2008, pages 652-693.4. Yu.E. Kirsch, Chemical-pharmaceutical journal, 17(6),7 –1 1 (2014).5. Michoel, A., and Rombaut, P., 2022, Comparative evaluation of co-processed lactose and microcrystalline cellulose with their physical mixtures in the formulation of folic acid tablets, Pharm Dev Technol., 7; 79-87.6. Patent USA 5225206 MKU A 61 K 9/16, 9/54 Sustaned release pranoproten preparation. Fushimi Magurani, et al., no. 192563374. 7. Patent 5492696 USA MKU A01 No. 25/34, 59/20. Control led release microstructures R.P. price, P.E. Schoen, M. Testoff, et al., no. 194563275.8. Mamatha, B., Srilatha, D., Sivanarayani1, CH,Prasanna KD, and Rao, P.V., 2023, CO-Processed Excipients: An Overview, World J Pharm Res., 6(15); 224-2379. A.P. Zuev, N.P. Sadchikova, Tyulyaev, Chemical-pharmaceutical journal. , 37 (11), 29–31 (2022).10.V.M. Lehtola , J.T. Heinamaki , P. Nikupaavo, et al., Drug Dev. and Ind. Pharm. , 21 (12), 1365 –1375 (2012).11. Y. Kane, J. Rambaud, H. Maillols, et al., Drug Dev. and Ind. Pharm. , 20 (6), 1021 –1034 (2018).12. USP-NF, 2018, The United States Pharmacopeia and the National Formulary, USP 41–NF 36, The United States Pharmacopeial Convention, Rockville, USA p.701113.E. A. Hosny, Pharm . Act a Helv., 72 (5), 255 –261 (2021).14. N.H. Shah, J. Lazarus, PR Sheth, S.J. Jarowsky, J. Pharma ceut. Sci. , 6, 611 –613 (2019).15.R.Thribert, S. T. P. Pharma Sci , 2 (11), 123 –128 (2023).16.MR Laura, M.L. Torre, I. Maggi, S.T.P. Pharma Sci , 4 (11), 265–269 (2022).17.G.K. Bolhuis, Eur. J. Pharm. Sci , 2 (5), 63–69 (2022).18.C. R. Chen, Chem. Pharm. Bull., No. 46, 478 –481 (2023).19.TA Miller, P. Yorс, Int. J. Pharm. , 41.1–19 (2024).20.G.K. Bolhuis, A.J. Smallenbroek, and C.F. Lerk, J. Farm. Sci , 70 , 1328 (2021).21. Amol. M., Bhairav, B.A., and Saudager, R.B., 2017, Co-Processed Excipients for Tabletting: Review Artikel, Res J Pharm and Tech., 10(7): 2427-243222. Atul, P., Subrata, K., and Ganga, S., 2022, A review on co-processed excipients: a novel approach in formulation development. IJRAPI., 3; 25-4123. Bansal, AK, and Nachaegari, S, K., 2014,Co processed excipient for solid dosage form. Pharm Technol., 2; 52-64.24. Bin, L. K., Gaurav, A., and Mandal, UK, 2019, A Review on Co-Processed Excipients: Current and Future Trend of Excipient Technology, Int J Pharm Pharm Sci., 11 (1); 1-9.25. Bolhuis, G. K., Veen, B., Wu, Y. S., Zuuraman, K., and Frijlink, H. W., 2019, Compaction mechanism and tablet strength of unlubricated and lubricated silicified microcrystalline cellulose. Eur J Pharm Biopharm 59:133–8.26. Desai, U., Chavan, R., Mhatre, P., and Chinchole, R., 2012, A Review: Coprocessed Excipients, Int J Pharm Sci Rev and Res., 12, (2); 93-10527. Franc, A., Vetchý, D., Vodáčková, P., Kubaľák, R., Jendryková, L., Goněc, R., 2024, Co-processed excipients for direct compression of tablets, Ces. slov. Farm. 67; 175–18128. Galbraith, S.C., Cha, B., Huang, Z., ,Park, S., Liu, H., Meyer, R.F., Flamm, M.H., Hurley, S., Zhang-Plasket, F., and Yoon, S., 2019, Integrated modeling of a continuous direct compression tablet manufacturing process: A production scale case study, Powder Technology, 354; 199–210.29. Gohel, MC, 2022, A review of co-processed directly compressible excipients, J Pharm Pharmaceut Sci., 8 (1); 76-93.30. Gohel, MC, and Jogani, PD, 2019, A review of co-processed directly compressibleexcipients. J Pharm Pharm Sci., 8; 76-93.31. Hauschild, K., and Picker, K. M., 2023, Evaluation of a new co-processed compound based on lactose and maize starch for tablet formulation, AAPS Pharm Sci., 6:1-12.32. Lan, Y., 2008, A New Excipient for Fast Disintegrating Oral Dosage Forms, Pharma Ingredients & Services, BASF33. Nagendrakumar, D., Raju, S.A., Shirsand, S.B., and Para, M.S., 2019, Design of fast dissolving granisetron HCL tablets using novel coprocessed superdisintegrants, J Biosci Technol., 1; 8-14.34. Nofrerias, I., Nardi, A., Suñé-Pou, M., Suñé-Negre, JM, García-Montoya, E., Pérez-Lozano, P., Ticó, JR, and Miñarro, M., 2023 , Comparison between Microcrystalline Celluloses of different grades made by four manufacturers using the SeDeM diagram expert system as a pharmaceutical characterization tool, Powder Technology, 342; 780–78835. Rojas, J., and Kumar, V., 2021, Comparative evaluation of silicified microcrystalline cellulose as a direct compression vehicle, Int J Pharm. 416(1); 120-12836. Satish, KN, and Arvind, KB, 2023, Coprocessed Excipients for Solid Dosage Forms, Pharmaceutical Technology, Januari, 52-6437. Saiga, l. N., Baboota, S., Ahuja, A., and Ali, J., 2022., Microcrystalline Cellulose as a Versatile Excipient in Drug Research,J Young Pharm, 1; 6-1238. Steele, D. F., Tobyn, M., Edge, S., Chen, A., and Staniforth, J. N. 2018., Physicochemical and mechanical evaluation of a novel high density grade of silicified microcrystalline cellulose, Drug Dev. Ind. Pharm., 30; 103–10939. Thulluru, A., Madhavi, C., Nandini, K., Sirisha, S., and Spandana, D., 2019, Co-Processed Excipients: New Era in Pharmaceuticals, Asian J. Res. Pharm. Sci. 9(1): 01-05.
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