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Hypertension, or high blood pressure, is one of the primary causes of cardiovascular diseases and mortality worldwide. Effective management involves lifestyle changes and pharmacological interventions. Among antihypertensive drugs, Angiotensin-Converting Enzyme (ACE) inhibitors (e.g., Enalapril) and Calcium Channel Blockers (CCBs) (e.g., Amlodipine) are frequently prescribed. While both drug classes effectively reduce blood pressure, they differ in mechanisms of action, safety profiles, and long-term cardiovascular outcomes. This review aims to analyze and compare the efficacy, safety, and tolerability of ACE inhibitors and calcium channel blockers based on existing literature, identify research gaps, and provide insights into optimizing their use in hypertension management

  • Read count 39
  • Date of publication 31-12-2024
  • Main LanguageIngliz
  • Pages 22-26
English

Hypertension, or high blood pressure, is one of the primary causes of cardiovascular diseases and mortality worldwide. Effective management involves lifestyle changes and pharmacological interventions. Among antihypertensive drugs, Angiotensin-Converting Enzyme (ACE) inhibitors (e.g., Enalapril) and Calcium Channel Blockers (CCBs) (e.g., Amlodipine) are frequently prescribed. While both drug classes effectively reduce blood pressure, they differ in mechanisms of action, safety profiles, and long-term cardiovascular outcomes. This review aims to analyze and compare the efficacy, safety, and tolerability of ACE inhibitors and calcium channel blockers based on existing literature, identify research gaps, and provide insights into optimizing their use in hypertension management

№ Author name position Name of organisation
1 Obidova R.O. Assistant Central Asian Medical University
2 Gayratjonova Z.G. Assistant Central Asian Medical University
№ Name of reference
1 1.White WB, Greenberg M, Chen J. Adverse effects of calcium channel blockers: A comprehensive review. Cardiovascular Medicine. 2020;18(5):234-40.2.Lee C, Kim H, Park S. Efficacy of Amlodipine in reducing stroke risk: Insights from a meta-analysis. Neurology and Cardiovascular Reports. 2016;22(3):198-204.3.Brown M, Zhao Y, Singh P. Mechanisms and incidence of ACE inhibitor-induced cough. Pharmacological Reviews. 2017;25(1):45-52.4.Johnson P, Davis L, Nguyen T. Comparative analysis of arterial stiffness reduction by antihypertensive agents. Vascular Health and Risk Management. 2019;15(3):89-97.5.Smith R, Johnson T, Patel M. Comparative efficacy of ACE inhibitors vs. calcium channel blockers. Hypertension Journal. 2018;12(4):345-50.6.Garcia S, Ahmed Z, Lopez R. The reno-protective effects of ACE inhibitors in diabetic hypertensive patients. Journal of Diabetes and Hypertension. 2015;14(2):123-9.
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