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Background. The COVID-19 pandemic poses a significant health risk for pregnant women. Due to physiological immunosuppression during pregnancy, the risk of severe COVID-19 and complications in pregnant women is higher. Thus, studying the safety and efficacy of COVID-19 vaccination during pregnancy is a pressing issue.Aim. Toevaluate the safety and efficacy of COVID-19 vaccination during pregnancy and its impact on perinatal outcomes.Materials and Methods. The study included 150 pregnant women, 120 of whom were vaccinated against COVID-19, while 30 formed the control group. Vaccinated women were divided into two groups based on their pregnancy term: II and III trimesters. Hemostasis, fetoplacental system, hormones, cytokines, and immunogenicity levels were assessed. Statistical analysis was conducted using significance levels(р<0.05, р<0.01, р<0.001).Results. Vaccinated women showed normal fetoplacental system and hemostasis indicators. Hormone and cytokine levels remained within physiological limits. IgG antibodies to SARS-CoV-2 were detected in 87% of vaccinated women. IgGtiters increased significantly at 3, 6, and 9 months after vaccination. Preterm births were 1.5 times less frequent among vaccinated women compared to unvaccinated ones. The Apgar score for newborns was 8-9 points in most cases. The incidence of respiratory infections among newborns was 1.7 times lower

  • Read count 34
  • Date of publication 31-12-2024
  • Main LanguageIngliz
  • Pages58-73
English

Background. The COVID-19 pandemic poses a significant health risk for pregnant women. Due to physiological immunosuppression during pregnancy, the risk of severe COVID-19 and complications in pregnant women is higher. Thus, studying the safety and efficacy of COVID-19 vaccination during pregnancy is a pressing issue.Aim. Toevaluate the safety and efficacy of COVID-19 vaccination during pregnancy and its impact on perinatal outcomes.Materials and Methods. The study included 150 pregnant women, 120 of whom were vaccinated against COVID-19, while 30 formed the control group. Vaccinated women were divided into two groups based on their pregnancy term: II and III trimesters. Hemostasis, fetoplacental system, hormones, cytokines, and immunogenicity levels were assessed. Statistical analysis was conducted using significance levels(р<0.05, р<0.01, р<0.001).Results. Vaccinated women showed normal fetoplacental system and hemostasis indicators. Hormone and cytokine levels remained within physiological limits. IgG antibodies to SARS-CoV-2 were detected in 87% of vaccinated women. IgGtiters increased significantly at 3, 6, and 9 months after vaccination. Preterm births were 1.5 times less frequent among vaccinated women compared to unvaccinated ones. The Apgar score for newborns was 8-9 points in most cases. The incidence of respiratory infections among newborns was 1.7 times lower

№ Author name position Name of organisation
1 Shukurov F.I. ! Tashkent Medical Academy
2 Mamazhonova D.M. ! Tashkent Medical Academy
№ Name of reference
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