ЭФФЕКТИВНЫЕ МЕТОДЫ ЛЕЧЕНИЯ И ПРОФИЛАКТИКИ ОТОМИКОЗА

Nugmanov Ozodbek Juraboy ugli; Raximov  Solijon  Komiljonovich; Abdumutalipov Ulugbek Shuxrat ogli Ulugbek  Shuxrat ogli; Xaydarov  Ilxomjon  Ikromjon ogli

doi:10.24411/2181-0443/2020-10127

463

Отомикоз - заболевание, вызываемое плесневыми и дрожжеподобными грибами. Поражает среднее и внешнее ухо. Иногда после операции грибок рецидивирует. К тому же с одинаковой частотой страдают и взрослые, и дети. Риск заболевания заключается в том, что на ранних стадиях развития оно протекает практически бессимптомно. Инфекция часто обнаруживается только после возникновения серьезных осложнений. В этой статье рассказывается о лечении и профилактике отомикоза.

Журнал номиRE-HEALTH
Нашр номи3.2-2020
Кўришлар сони 463

Internet ҳавола https://cyberleninka.ru/article/n/effektivnye-metody-lecheniya-i-profilaktiki-otomikoza

DOI10.24411/2181-0443/2020-10127

UzSCI тизимида яратилган сана 31-01-2021

Ўқишлар сони 398

Нашр санаси 31-01-2021

Мақола тилиRus

Саҳифалар сониЭФФЕКТИВНЫЕ МЕТОДЫ ЛЕЧЕНИЯ И ПРОФИЛАКТИКИ ОТОМИКОЗА

Калит сўзлар

частота

отомикоз

плесень

Русский

Отомикоз - заболевание, вызываемое плесневыми и дрожжеподобными грибами. Поражает среднее и внешнее ухо. Иногда после операции грибок рецидивирует. К тому же с одинаковой частотой страдают и взрослые, и дети. Риск заболевания заключается в том, что на ранних стадиях развития оно протекает практически бессимптомно. Инфекция часто обнаруживается только после возникновения серьезных осложнений. В этой статье рассказывается о лечении и профилактике отомикоза.

Калит сўзлар

частота

отомикоз

плесень

Ўзбек

Otomikoz - bu mog'or va xamirturushga o'xshash zamburug'lar keltirib chiqaradigan kasallik. O'rta va tashqi quloqqa ta'sir qiladi. Ba'zida zamburug’larning ko'payishi operatsiyadan keyin sodir bo'ladi. Bundan tashqari, kattalar ham, bolalar ham bir xil chastotada aziyat chekishadi. Kasallikning xavfi uning rivojlanishning dastlabki bosqichlarida deyarli asimptomatik bo'lishidadir. Infektsiya ko'pincha jiddiy asoratlar paydo bo'lgandan keyingina aniqlanadi. Ushbu maqolada otomikoz kasalligini davolash va oldini olish bo’yicha muhokama qilinadi.

Калит сўзлар

Chastota

Otomikoz

mog’or

English

Otomycosis is a disease caused by mold and yeast-like fungi. Affects the middle and outer ear. Occasionally there is a recurrence of the fungus after surgery. In addition, both adults and children suffer at the same frequency. The risk of the disease is that it is almost asymptomatic in the early stages of its development. Infection is often detected only after serious complications have occurred. This article discusses the treatment and prevention of otomycosis

Калит сўзлар

frequency

Otomycosis

mold

№ Муаллифнинг исми Лавозими Ташкилот номи

1 Nugmanov O.J. . ASMI

2 Raximov S.K. . ASMI

3 Abdumutalipov Ulugbek Shuxrat ogli U.S. . ASMI

4 Xaydarov I.I. . ASMI

№ Ҳавола номи

1 1. Medically reviewed by Daniel Murrell, M.D. — Written by Shannon Johnson on May 24, 2018. What to know about otomycosis.

2 2. Jimenez-Garcia, L., Celis-Aguilar, E., Díaz-Pavón, G., Muñoz Estrada, V., Castro-Urquizo, Á., Hernández-Castillo, N., & Amaro-Flores, E. (2019). Efficacy of topical clotrimazole vs. topical tolnaftate in the treatment of otomycosis. A randomized controlled clinical trial. Brazilian Journal of Otorhinolaryngology. doi:10.1016/j.bjorl.2018.12.007

3 3. Vega-Nava CT, Borrego-Montoya CR, Vásquez-Del Mercado E, Vega-Sánchez DC, Arenas R. Otitis externa de origen fúngico. Estudio de 36 pacientes en un hospital general. An Orl Mex. 2015;60:175---8.

4 4. Linstrom C, Lucente F. Diseases of the external ear. In: Bailey J, Johnson T, Newlands D, editors. Head & neck surgeryotolaryngology. Philadelphia, PA: Lippincott Williams & Wilkins; 2014. p. 1987---2002.

5 5. Rosenfeld RM, Brown L, Cannon CR, Dolor RJ, Ganiats TG, Hannley M, et al. Clinical practice guideline: acute otitis externa. Otolaryngol Head Neck Surg. 2006;134:S4---23.

6 6. Barati B, Okhovvat S, Goljanian A, Omrani M. Otomycosis in central Iran: a clinical and mycological study. Iran Red Crescent Med J. 2011;13:873---6.

7 7. Grunstein E, Santos F, Selesnick S. Trastornos de oído externo. In: Lawlani A, editor. Current Diagnóstico y tratamiento en Otorrinolaringología y cirugía de cabeza y cuello. New York, NY: McGraw Hill; 2009. p. 624---40.

8 8. Prasad SC, Kotigadde S, Shekhar M, Thada ND, Prabhu P, D’Souza T. Primary otomycosis in the Indian subcontinent: predisposing factors, microbiology, and classification. Int J Microbiol. 2014;2014:1---9.

9 9. Pontes ZB, Silva AD, Lima E, Guerra M, Oliviera N, Carvalho M, et al. Otomycosis: a retrospective study. Braz J Otorhinolaryngol. 2009;75:367---70.

10 10. Moghadam AY, Asadi MA, Dehghani R, Mahmoudabadi AZ, Rayegan F, Hooshyar H, et al. Evaluating the effect of a mixture of alcohol and acetic acid for otomycosis therapy. Jundishapur J Microbiol. 2010;3:66---70.

11 11. Stern JC, Lucente FE. Otomycosis. Ear Nose Throat J. 1988;67:804---10.

12 12. Malik AA, Malik SN, Aslam MA, Rasheed D. Comparative efficacy of topical clotrimazole and 3% salicylic acid in otomycosis. Rawal Med J. 2012;13:46---9.

13 13. Ruz S, Breinbauer H, Corssen C. Otitis externa micótica y perforación timpánica: reporte de dos casos. Rev Otorrinolaringol Cir Cabeza Cuello. 2010;70:245---52.

14 14. Munguía R, Daniel SJ. Ototopical antifungals and otomycosis: a review. Int J Pediatr Otorhinolaryngol. 2008;72:453---9.

15 15. Fasunla J, Ibekwe T, Onakoya P. Otomycosis in western Nigeria. Mycoses. 2008;51:67---70.

16 16. Khan F, Muhammad R, Khan MR, Rehman F, Iqbal J, Khan M, et al. Efficacy of topical clotrimazole in treatment of otomycosis. J Ayub Med Coll Abbottabad. 2013;25:78---80.

17 17. Instituto Nacional de Estadística e Informática INEGI [INEGI website].

18 18. Wiswanta B, Naseerudddin Kh. Fungal infections of the ear in Immunocompromised host: a review. Mediterr J Hematol Infect Dis. 2011;3:e2011003.

19 19. Paulose KO, Al-Khalifa S, Shenoy P. Mycotic infection of the ear (otomycosis): a prospective study. J Laryngol Otol. 1989;103:3---5.

20 20. Ozcan MK, Ozcan M, Karaarslan A, Karaarslan F. Otomycosis in Turkey: predisposing factors, aetiology and therapy. J Laryngol Otol. 2003;117:39---42.

21 21. Ghiacei S. Survey of otomycosis in north-western area of Iran. Med J Mashhad Uni Med Sci. 2001;43:85---7.

22 22. Nowrozi H, Arabi FD, Mehraban HG, Tavakoli A, Ghooshchi G. Mycological and clinical study of otomycosis in Tehran, Iran. Bull Environ Pharmacol Life Sci. 2014;3:29---

23 23. Kurnatowski P, Filipiak A. Otomycosis: prevalence, clinical symptoms, therapeutic procedure. Mycoses. 2001;44:472---9.

24 24. Mgbor N, Gugnani HC. Otomycosis in Nigeria: treatment with mercurochrome. Mycoses. 2001;44:395---7.

25 25. Hueso-Gutiérrez P, Jiménez-Alvarez S, Gil-Carcedo E, GilCarcedo L, Ramos-Sánchez C, Vallejo-Valdezate L. Presumed diagnosis: otomycosis. A study of 451 patients. Acta Otorrinolaryngol Esp. 2005;56:181---6.

26 26. Mishra GS, Mehta N, Pal M. Chronic bilateral otomycosis caused by aspergillus niger. Mycoses. 2004;47:82---4.

27 27. Araiza J, Canseco P, Bonifaz A. Otomycosis: clinical and mycological study of 97 cases. Rev Laryngol Otol Rhinol. 2006;127:251---4.

28 28. Kaur R, Mittal N, Kakkar M, Aggarwal AK, Mathur MD. Otomycosis: a clinicomycologic study. Ear Nose Throat J. 2000;79:606---9. 29. Jadhav VJ, Pai M, Mishra G. Etiological significance of Candida albicans in otitis externa. Mycopathologica. 2003;156:313---5.

29 29. Jackman A. Case report topical antibiotic induced otomycosis. Int J Pediatr Otorhinolaryngol. 2005;69:957---60.

30 30. Li Y, He L. Diagnosis and treatment of otomycosis in southern China. Mycoses. 2019;62(11):1064-1068.

31 31. Gharaghani M, Seifi Z, Zarei MA. Otomycosis in Iran: a review. Mycopathologia. 2015;179(5-6):415-424.

32 32. Koltsidopoulos P, Skoulakis C. Otomycosis with tympanic membrane perforation: a review of the literature [published online May 29, 2019]. Ear Nose Throat J. doi:10.1177/0145561319851499.

33 33. Punia RS, Singhal SK, Kundu R, Das A, Chander J. Fungal suppurative otitis media (histopathology) among patients in North India. Head Neck Pathol. 2019;13(2):149-153.

34 34. Arndal E, Glad H, Homøe P. Large discrepancies in otomycosis treatment in private ear, nose, and throat clinics in Denmark. Dan Med J. 2016;63(5):A5231.

35 35. Romsaithong S, Tomanakan K, Tangsawad W, Thanaviratananich S. Effectiveness of 3 per cent boric acid in 70 per cent alcohol versus 1 per cent clotrimazole solution in otomycosis patients: a randomised, controlled trial. J Laryngol Otol. 2016;130(9):811-815

36 36. Mofatteh MR, Naseripour YZ, Yousefi M, Namaei MH. Comparison of the recovery rate of otomycosis using betadine and clotrimazole topical treatment. Braz J Otorhinolaryngol. 2018;84(4):404-409.

37 37. Philip A, Thomas R, Job A, Sundaresan VR, Anandan S, Albert RR. Effectiveness of 7.5 percent povidone iodine in comparison to 1 percent clotrimazole with lignocaine in the treatment of otomycosis. ISRN Otolaryngol. 2013;2013:239730.

38 38. Anwar K, Gohar MS. Otomycosis; clinical features, predisposing factors and treatment implications. Pak J Med Sci. 2014;30(3):564-567.

39 39. Kiakojori K, Bagherpour JN, Khafri S, Mahdavi OS. Assessment of response to treatment in patients with otomycosis. Iran J Otorhinolaryngol. 2018;30(96):41-47.

40 40. Dundar R, İynen İ. Single dose topical application of clotrimazole for the treatment of otomycosis: is this enough? J Audiol Otol. 2019;23(1):15-19.

41 41. Zhang, S., Jin, M., Hu, S., Zhang, Y., & Zhou, G. (2020). Administration of 1% topical voriconazole drops was effective and safe in the treatment of refractory otomycosis without tympanic membrane perforation. Annals of Otology, Rhinology & Laryngology, 000348942094678. doi:10.1177/0003489420946783.

42 42. Treatment of otomycosis with acetic acid and boric acid otomikozun asetik as it ve borik asitle teda vis i. Mustafa erkan, tahsln asian, omit soyuer.

43 43. Stern JC, Lucente F : Otomycosis. Ear Nose Throat J 67:809-810,1988.

44 44. Stern JC, Shah MK, Lucente FE: In vitro effectiveness of 13 agents in otomycosis and review of the literature. Laryngoscope 98: 1173-1177, 1988.

45 45. Than KM, Kyaw SN, Myo M: Otomycosis in Burma, and its treatement. Am J Trop Med Hyg 29:620-623,1980.

Кутилмоқда

№	Муаллифнинг исми	Лавозими	Ташкилот номи
1	Nugmanov O.J.	.	ASMI
2	Raximov S.K.	.	ASMI
3	Abdumutalipov Ulugbek Shuxrat ogli U.S.	.	ASMI
4	Xaydarov I.I.	.	ASMI

№	Ҳавола номи
1	1. Medically reviewed by Daniel Murrell, M.D. — Written by Shannon Johnson on May 24, 2018. What to know about otomycosis.
2	2. Jimenez-Garcia, L., Celis-Aguilar, E., Díaz-Pavón, G., Muñoz Estrada, V., Castro-Urquizo, Á., Hernández-Castillo, N., & Amaro-Flores, E. (2019). Efficacy of topical clotrimazole vs. topical tolnaftate in the treatment of otomycosis. A randomized controlled clinical trial. Brazilian Journal of Otorhinolaryngology. doi:10.1016/j.bjorl.2018.12.007
3	3. Vega-Nava CT, Borrego-Montoya CR, Vásquez-Del Mercado E, Vega-Sánchez DC, Arenas R. Otitis externa de origen fúngico. Estudio de 36 pacientes en un hospital general. An Orl Mex. 2015;60:175---8.
4	4. Linstrom C, Lucente F. Diseases of the external ear. In: Bailey J, Johnson T, Newlands D, editors. Head & neck surgeryotolaryngology. Philadelphia, PA: Lippincott Williams & Wilkins; 2014. p. 1987---2002.
5	5. Rosenfeld RM, Brown L, Cannon CR, Dolor RJ, Ganiats TG, Hannley M, et al. Clinical practice guideline: acute otitis externa. Otolaryngol Head Neck Surg. 2006;134:S4---23.
6	6. Barati B, Okhovvat S, Goljanian A, Omrani M. Otomycosis in central Iran: a clinical and mycological study. Iran Red Crescent Med J. 2011;13:873---6.
7	7. Grunstein E, Santos F, Selesnick S. Trastornos de oído externo. In: Lawlani A, editor. Current Diagnóstico y tratamiento en Otorrinolaringología y cirugía de cabeza y cuello. New York, NY: McGraw Hill; 2009. p. 624---40.
8	8. Prasad SC, Kotigadde S, Shekhar M, Thada ND, Prabhu P, D’Souza T. Primary otomycosis in the Indian subcontinent: predisposing factors, microbiology, and classification. Int J Microbiol. 2014;2014:1---9.
9	9. Pontes ZB, Silva AD, Lima E, Guerra M, Oliviera N, Carvalho M, et al. Otomycosis: a retrospective study. Braz J Otorhinolaryngol. 2009;75:367---70.
10	10. Moghadam AY, Asadi MA, Dehghani R, Mahmoudabadi AZ, Rayegan F, Hooshyar H, et al. Evaluating the effect of a mixture of alcohol and acetic acid for otomycosis therapy. Jundishapur J Microbiol. 2010;3:66---70.
11	11. Stern JC, Lucente FE. Otomycosis. Ear Nose Throat J. 1988;67:804---10.
12	12. Malik AA, Malik SN, Aslam MA, Rasheed D. Comparative efficacy of topical clotrimazole and 3% salicylic acid in otomycosis. Rawal Med J. 2012;13:46---9.
13	13. Ruz S, Breinbauer H, Corssen C. Otitis externa micótica y perforación timpánica: reporte de dos casos. Rev Otorrinolaringol Cir Cabeza Cuello. 2010;70:245---52.
14	14. Munguía R, Daniel SJ. Ototopical antifungals and otomycosis: a review. Int J Pediatr Otorhinolaryngol. 2008;72:453---9.
15	15. Fasunla J, Ibekwe T, Onakoya P. Otomycosis in western Nigeria. Mycoses. 2008;51:67---70.
16	16. Khan F, Muhammad R, Khan MR, Rehman F, Iqbal J, Khan M, et al. Efficacy of topical clotrimazole in treatment of otomycosis. J Ayub Med Coll Abbottabad. 2013;25:78---80.
17	17. Instituto Nacional de Estadística e Informática INEGI [INEGI website].
18	18. Wiswanta B, Naseerudddin Kh. Fungal infections of the ear in Immunocompromised host: a review. Mediterr J Hematol Infect Dis. 2011;3:e2011003.
19	19. Paulose KO, Al-Khalifa S, Shenoy P. Mycotic infection of the ear (otomycosis): a prospective study. J Laryngol Otol. 1989;103:3---5.
20	20. Ozcan MK, Ozcan M, Karaarslan A, Karaarslan F. Otomycosis in Turkey: predisposing factors, aetiology and therapy. J Laryngol Otol. 2003;117:39---42.
21	21. Ghiacei S. Survey of otomycosis in north-western area of Iran. Med J Mashhad Uni Med Sci. 2001;43:85---7.
22	22. Nowrozi H, Arabi FD, Mehraban HG, Tavakoli A, Ghooshchi G. Mycological and clinical study of otomycosis in Tehran, Iran. Bull Environ Pharmacol Life Sci. 2014;3:29---
23	23. Kurnatowski P, Filipiak A. Otomycosis: prevalence, clinical symptoms, therapeutic procedure. Mycoses. 2001;44:472---9.
24	24. Mgbor N, Gugnani HC. Otomycosis in Nigeria: treatment with mercurochrome. Mycoses. 2001;44:395---7.
25	25. Hueso-Gutiérrez P, Jiménez-Alvarez S, Gil-Carcedo E, GilCarcedo L, Ramos-Sánchez C, Vallejo-Valdezate L. Presumed diagnosis: otomycosis. A study of 451 patients. Acta Otorrinolaryngol Esp. 2005;56:181---6.
26	26. Mishra GS, Mehta N, Pal M. Chronic bilateral otomycosis caused by aspergillus niger. Mycoses. 2004;47:82---4.
27	27. Araiza J, Canseco P, Bonifaz A. Otomycosis: clinical and mycological study of 97 cases. Rev Laryngol Otol Rhinol. 2006;127:251---4.
28	28. Kaur R, Mittal N, Kakkar M, Aggarwal AK, Mathur MD. Otomycosis: a clinicomycologic study. Ear Nose Throat J. 2000;79:606---9. 29. Jadhav VJ, Pai M, Mishra G. Etiological significance of Candida albicans in otitis externa. Mycopathologica. 2003;156:313---5.
29	29. Jackman A. Case report topical antibiotic induced otomycosis. Int J Pediatr Otorhinolaryngol. 2005;69:957---60.
30	30. Li Y, He L. Diagnosis and treatment of otomycosis in southern China. Mycoses. 2019;62(11):1064-1068.
31	31. Gharaghani M, Seifi Z, Zarei MA. Otomycosis in Iran: a review. Mycopathologia. 2015;179(5-6):415-424.
32	32. Koltsidopoulos P, Skoulakis C. Otomycosis with tympanic membrane perforation: a review of the literature [published online May 29, 2019]. Ear Nose Throat J. doi:10.1177/0145561319851499.
33	33. Punia RS, Singhal SK, Kundu R, Das A, Chander J. Fungal suppurative otitis media (histopathology) among patients in North India. Head Neck Pathol. 2019;13(2):149-153.
34	34. Arndal E, Glad H, Homøe P. Large discrepancies in otomycosis treatment in private ear, nose, and throat clinics in Denmark. Dan Med J. 2016;63(5):A5231.
35	35. Romsaithong S, Tomanakan K, Tangsawad W, Thanaviratananich S. Effectiveness of 3 per cent boric acid in 70 per cent alcohol versus 1 per cent clotrimazole solution in otomycosis patients: a randomised, controlled trial. J Laryngol Otol. 2016;130(9):811-815
36	36. Mofatteh MR, Naseripour YZ, Yousefi M, Namaei MH. Comparison of the recovery rate of otomycosis using betadine and clotrimazole topical treatment. Braz J Otorhinolaryngol. 2018;84(4):404-409.
37	37. Philip A, Thomas R, Job A, Sundaresan VR, Anandan S, Albert RR. Effectiveness of 7.5 percent povidone iodine in comparison to 1 percent clotrimazole with lignocaine in the treatment of otomycosis. ISRN Otolaryngol. 2013;2013:239730.
38	38. Anwar K, Gohar MS. Otomycosis; clinical features, predisposing factors and treatment implications. Pak J Med Sci. 2014;30(3):564-567.
39	39. Kiakojori K, Bagherpour JN, Khafri S, Mahdavi OS. Assessment of response to treatment in patients with otomycosis. Iran J Otorhinolaryngol. 2018;30(96):41-47.
40	40. Dundar R, İynen İ. Single dose topical application of clotrimazole for the treatment of otomycosis: is this enough? J Audiol Otol. 2019;23(1):15-19.
41	41. Zhang, S., Jin, M., Hu, S., Zhang, Y., & Zhou, G. (2020). Administration of 1% topical voriconazole drops was effective and safe in the treatment of refractory otomycosis without tympanic membrane perforation. Annals of Otology, Rhinology & Laryngology, 000348942094678. doi:10.1177/0003489420946783.
42	42. Treatment of otomycosis with acetic acid and boric acid otomikozun asetik as it ve borik asitle teda vis i. Mustafa erkan, tahsln asian, omit soyuer.
43	43. Stern JC, Lucente F : Otomycosis. Ear Nose Throat J 67:809-810,1988.
44	44. Stern JC, Shah MK, Lucente FE: In vitro effectiveness of 13 agents in otomycosis and review of the literature. Laryngoscope 98: 1173-1177, 1988.
45	45. Than KM, Kyaw SN, Myo M: Otomycosis in Burma, and its treatement. Am J Trop Med Hyg 29:620-623,1980.