Cardiovascular risk factors contribute to the development of cardiovascular disease and their presence may affect the level of microRNA
expression in patients with ST-elevation myocardial infarction. So far, only a few reports have been published describing the relationship between
microRNA expression and the presence of cardiovascular risk factors.
Aim
Evaluation of microRNA expression in patients with ST- elevation myocardial infarction with present cardiovascular risk factors.
Materials & Methods
Seventeen patients with ST-elevation myocardial infarction were examined. MicroRNA expression (miR-1, miR-208a i miR-423-5p) was
determined according to the Pfaffla model and then compared between two groups: with and without cardiovascular risk factors.
Results
Higher expression levels of microRNAs were found in smokers. Lower levels of miR-1, miR-208a and miR-423-5p expression were found in
patients with increased lipid levels or these using hypolipemic drugs.
Conclusion
MicroRNA expression in patients with ST-elevation myocardial infarction depends on the presence of some cardiovascular risk factors.
Cardiovascular risk factors contribute to the development of cardiovascular disease and their presence may affect the level of microRNA
expression in patients with ST-elevation myocardial infarction. So far, only a few reports have been published describing the relationship between
microRNA expression and the presence of cardiovascular risk factors.
Aim
Evaluation of microRNA expression in patients with ST- elevation myocardial infarction with present cardiovascular risk factors.
Materials & Methods
Seventeen patients with ST-elevation myocardial infarction were examined. MicroRNA expression (miR-1, miR-208a i miR-423-5p) was
determined according to the Pfaffla model and then compared between two groups: with and without cardiovascular risk factors.
Results
Higher expression levels of microRNAs were found in smokers. Lower levels of miR-1, miR-208a and miR-423-5p expression were found in
patients with increased lipid levels or these using hypolipemic drugs.
Conclusion
MicroRNA expression in patients with ST-elevation myocardial infarction depends on the presence of some cardiovascular risk factors.
| № | Муаллифнинг исми | Лавозими | Ташкилот номи |
|---|---|---|---|
| 1 | Edyta N.. | ассистент | Sileziya tibbiyot universiteti |
| 2 | Maciej K.. | ассистент | Sileziya tibbiyot universiteti |
| № | Ҳавола номи |
|---|---|
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