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Tuberculosis (TB) remains a significant global health challenge, affecting millions of individuals each year. While primarily known as a respiratory disease, TB can also impact the central nervous system (CNS), leading to serious neurological complications. This article provides an overview of the damage caused by TB to the CNS, encompassing various manifestations such as tuberculous meningitis, tuberculoma, and spinal TB. Through a review of current literature, the mechanisms of CNS involvement in TB, diagnostic modalities, and treatment strategies are discussed. Understanding the neurological consequences of TB is crucial for timely diagnosis and effective management, ultimately improving patient outcomes and reducing morbidity associated with this devastating disease

  • Ўқишлар сони 26
  • Нашр санаси 01-05-2024
  • Мақола тилиIngliz
  • Саҳифалар сони101-106
English

Tuberculosis (TB) remains a significant global health challenge, affecting millions of individuals each year. While primarily known as a respiratory disease, TB can also impact the central nervous system (CNS), leading to serious neurological complications. This article provides an overview of the damage caused by TB to the CNS, encompassing various manifestations such as tuberculous meningitis, tuberculoma, and spinal TB. Through a review of current literature, the mechanisms of CNS involvement in TB, diagnostic modalities, and treatment strategies are discussed. Understanding the neurological consequences of TB is crucial for timely diagnosis and effective management, ultimately improving patient outcomes and reducing morbidity associated with this devastating disease

№ Муаллифнинг исми Лавозими Ташкилот номи
1 Kurbanov A.K. Assistant Tashkent Pediatric Medical Institute
2 Kuldoshov A.S. Assistant Tashkent Pediatric Medical Institute
3 Shamshieva N.N. Assistant Tashkent Pediatric Medical Institute
№ Ҳавола номи
1 1.World Health Organization. (2021). Global Tuberculosis Report 2021. Retrieved from https://www.who.int/publications/i/item/97892400370212.Rajshekhar, V., Chandy, M. J., & Santosh, V. (2012). Tuberculosis of the central nervous system: A review of the contemporary aspects of diagnosisand management. Journal of the Neurological Sciences, 316(1-2), 35-45.3.Thwaites, G. E., & van Toorn, R. (2019). Tuberculous meningitis: More questions, still too few answers. The Lancet Neurology, 18(3), 250-260.4.Garg, R. K., & Malhotra, H. S. (2011). Spinal tuberculosis. The Indian Journal of Orthopaedics, 45(1), 1-2.5.Ramakrishnan, C. V., & Prabhakar, A. T. (2019). Central nervous system tuberculosis: Pathophysiology and imaging findings. Neuroimaging Clinics of North America, 29(4), 517-531.6.Thwaites, G. E., & van Toorn, R. (2019). Tuberculous meningitis: More questions, still too few answers. The Lancet Neurology, 18(3), 250-260.7.Marais, S., Thwaites, G., Schoeman, J. F., et al. (2010). Tuberculous meningitis: A uniform case definitionfor use in clinical research. The Lancet Infectious Diseases, 10(11), 803-812.8.Donald, P. R., Schoeman, J. F., & Beyers, N. (2005). Tuberculous meningitis and miliary tuberculosis: The rich focus revisited. The Journal of Infection, 50(3), 193-195.9.Youssef, D. M., Zick, J., & Adeoye, O. (2020). Intracranial tuberculoma. Neurologic Clinics, 38(2), 337-352.10.Garg, R. K., & Malhotra, H. S. (2011). Spinal tuberculosis. The Indian Journal of Orthopaedics, 45(1), 1-2.11.Jain, A. K., & Kumar, J. (2015). Tuberculosisof spine: Neurological deficit. European Spine Journal, 24(Suppl 4), 829-837.12.Tuli, S. M. (2007). Tuberculosis of the spine: A historical review. Clinical Orthopaedics and Related Research, 460, 29-38.13.Rock, R. B., Olin, M., Baker, C. A., et al. (2008). Central nervous system tuberculosis: Pathogenesis and clinical aspects. Clinical Microbiology Reviews, 21(2), 243-261.14.Donald, P. R., & Schaaf, H. S. (2009). Tuberculosis of the central nervous system in children. The Pediatric Infectious Disease Journal, 28(10), 797-800.15.Patel, V. B., Theron, G., Lenders, L., et al. (2010). Diagnostic accuracy of quantitative PCR (Xpert MTB/RIF) for tuberculous meningitis in a high burden setting: A prospective study. PLOS Medicine, 7(9), e1000376.16.World Health Organization. (2010). Treatment of tuberculosis: Guidelines. Retrieved from https://apps.who.int/iris/handle/10665/4416517.Prasad, K., Singh, M. B., & Ryan, H. (2016). Corticosteroids for managing tuberculous meningitis. The Cochrane Database of Systematic Reviews, (4),CD002244.18.Rajshekhar, V., Chandy, M. J., & Santosh, V. (2012). Tuberculosis of the central nervous system: A review of the contemporary aspects of diagnosis and management. Journal of the Neurological Sciences, 316(1-2), 35-45.19.Thwaites, G. E., & van Toorn, R. (2019). Tuberculous meningitis: More questions, still too few answers. The Lancet Neurology, 18(3), 250-260.
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