143

Yurak ishemik kasalligi (YuIK) butun dunyo bo'ylab salomatlik uchun jiddiy muammo bo'lib, uning patogeneziga turli xil xavf omillari yotadi. Ular orasida gipergomosisteinemiya potentsial o'zgartirilishi mumkin bo'lgan xavf omili sifatida paydo bo'ldi, bu e'tiborni talab qiladi. Ushbu maqola gipergomosisteinemiya bilan og'rigan bemorlarda YuIK ning xususiyatlarini o'rganib, uning epidemiologik ahamiyati, patofiziologik mexanizmlari va klinik oqibatlariga e'tibor qaratadi. Sharh gomosistein darajasining ko'tarilishi ateroskleroz va trombozni qanday qilib koronar arteriya kasalligi va miokard infarktiga olib kelishi mumkinligini tushuntirish uchun joriy adabiyotlarni sintez qiladi. Bundan tashqari, u gipergomosisteinemiyasi bo'lgan odamlarda YuIKni boshqarish uchun mo'ljallangan diagnostika muammolari va terapevtik strategiyalarni muhokama qiladi. Ushbu jihatlarni tushunish gomosistein darajasining oshishi bilan bog'liq YuIK global yukini kamaytirishga qaratilgan profilaktika choralari va davolash strategiyalarini optimallashtirish uchun juda muhimdir

  • Ўқишлар сони 143
  • Нашр санаси 10-12-2024
  • Мақола тилиO'zbek
  • Саҳифалар сони 153-159
Ўзбек

Yurak ishemik kasalligi (YuIK) butun dunyo bo'ylab salomatlik uchun jiddiy muammo bo'lib, uning patogeneziga turli xil xavf omillari yotadi. Ular orasida gipergomosisteinemiya potentsial o'zgartirilishi mumkin bo'lgan xavf omili sifatida paydo bo'ldi, bu e'tiborni talab qiladi. Ushbu maqola gipergomosisteinemiya bilan og'rigan bemorlarda YuIK ning xususiyatlarini o'rganib, uning epidemiologik ahamiyati, patofiziologik mexanizmlari va klinik oqibatlariga e'tibor qaratadi. Sharh gomosistein darajasining ko'tarilishi ateroskleroz va trombozni qanday qilib koronar arteriya kasalligi va miokard infarktiga olib kelishi mumkinligini tushuntirish uchun joriy adabiyotlarni sintez qiladi. Bundan tashqari, u gipergomosisteinemiyasi bo'lgan odamlarda YuIKni boshqarish uchun mo'ljallangan diagnostika muammolari va terapevtik strategiyalarni muhokama qiladi. Ushbu jihatlarni tushunish gomosistein darajasining oshishi bilan bog'liq YuIK global yukini kamaytirishga qaratilgan profilaktika choralari va davolash strategiyalarini optimallashtirish uchun juda muhimdir

English

Coronary heart disease (CHD) represents a significant global health concern, with a multifactorial pathogenesis involving various risk factors. Among these, hyperhomocysteinemia has emerged as a potentially modifiable risk factor requiring particular attention. This article examines the specific features of CHD in patients with hyperhomocysteinemia, addressing its epidemiological significance, pathophysiological mechanisms, and clinical implications. The review summarizes contemporary literature to elucidate how elevated homocysteine levels can lead to atherosclerosis, thrombosis, coronary heart disease, and myocardial infarction. Furthermore, it discusses diagnostic challenges and therapeutic strategies for managing CHD in individuals with hyperhomocysteinemia. Understanding these aspects is critical for optimizing preventive measures and treatment strategies aimed at reducing the global burden of CHD associated with elevated homocysteine levels

Русский

Ишемическая болезнь сердца (ИБС) является серьезной проблемой для здоровья во всем мире, в патогенезе которой лежат различные факторы риска. Среди них гипергомоцистеинемия выделилась как потенциально модифицируемый фактор риска, требующий особого внимания. В данной статье исследуются особенности ИБС у больных с гипергомоцистеинемией, рассматривается ее эпидемиологическое значение, патофизиологические механизмы и клинические последствия. Обзор обобщает современную литературу, чтобы объяснить, как повышение уровня гомоцистеина может привести к атеросклерозу и тромбозу, ишемической болезни сердца и инфаркту миокарда. Кроме того, в нем обсуждаются диагностические проблемы и терапевтические стратегии, направленные на ведение ИБС у людей с гипергомоцистеинемией. Понимание этих аспектов крайне важно для оптимизации профилактических мер и стратегий лечения, направленных на снижение глобального бремени ИБС, связанного с повышением уровня гомоцистеина

Муаллифнинг исми Лавозими Ташкилот номи
1 Shukurdjanova .M. Dotsent, Toshkent tibbiyot Akademiyasi,
2 Nizamov I.U. shifokor Toshkent tibbiyot Akademiyasi,
3 Muhammadiyev S.B. magistrant Toshkent tibbiyot Akademiyasi,
Ҳавола номи
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