1177

The aim of our pilot clinical study was direct determination of gadolinium accumulation in glial tumors of human brain after single intravenous administration of Magnevist. Study was carried out on samples of glial tumors of human brain extracted during standard brain surgery.Samples from five patients with glial tumors and single intravenous administration of Magnevist in different times before surgery were studied. Samples of two patients with glial tumors and without intravenous administration of Magnevist and other gadolinium containing compounds were studied as control. Gadolinium content in tumor tissues was analyzed by method of neutron activation analysis. It was found that in all five investigated samples gadolinium present in concentrations from 0.0093 to 0.2384 ng/mg (ppm) tumor tissue. In control samples, the gadolinium has not been detected. At present time, the clinical importance of detected effect of gadolinium accumulation in brain tumors after intravenous introduction of pharmacological chelate compounds of gadolinium is not clear enough. As free gadolinium is toxic, so the establishment of fact of gadolinium accumulation in brain tumors can appear significant for interpretation of various unexpected clinical effects in the future

  • Internet ҳавола medsport.uz
  • DOI
  • UzSCI тизимида яратилган сана 03-12-2019
  • Ўқишлар сони 1118
  • Нашр санаси 03-06-2018
  • Мақола тилиIngliz
  • Саҳифалар сони27-30
Ўзбек

Eksperimental klinik ishning maqsadi magnevistni bir tomir ichiga yuborishdan keyin inson miyasida glial o’smalarda gadolinining to’planishi aniqlandi. Glial o’smalari bo’lgan 5 nafar bemorning namunalari operatsiyadan oldin turli vaqtlarda magnezistni bir tomir ichiga yuborish orqali tekshirildi. Nazorat namunalari glial shishi bo’lgan 2 gastrointestinal kasallik va magneziyani va gadoliniyni o’z ichiga olgan boshqa preparatlarni tomir ichiga yuborishdan iborat edi. Shifokorlardagi to’qimalarda gadolin tarkibida neytron faollashuvi tahlil qilindi. Gadolinium tekshiruv namunalarida topilmadi. Bepul gadolinium toksik bo’lganligi sababli, miya o’smalari to’planishining paydo bo’lishi kelajakda turli kutilmagan klinik ta’sirlarni talqin qilish uchun muhimdir

English

The aim of our pilot clinical study was direct determination of gadolinium accumulation in glial tumors of human brain after single intravenous administration of Magnevist. Study was carried out on samples of glial tumors of human brain extracted during standard brain surgery.Samples from five patients with glial tumors and single intravenous administration of Magnevist in different times before surgery were studied. Samples of two patients with glial tumors and without intravenous administration of Magnevist and other gadolinium containing compounds were studied as control. Gadolinium content in tumor tissues was analyzed by method of neutron activation analysis. It was found that in all five investigated samples gadolinium present in concentrations from 0.0093 to 0.2384 ng/mg (ppm) tumor tissue. In control samples, the gadolinium has not been detected. At present time, the clinical importance of detected effect of gadolinium accumulation in brain tumors after intravenous introduction of pharmacological chelate compounds of gadolinium is not clear enough. As free gadolinium is toxic, so the establishment of fact of gadolinium accumulation in brain tumors can appear significant for interpretation of various unexpected clinical effects in the future

Русский

Целью экспериментально-клинического исследования было прямое определение накопления гадолиния в глиальных опухолях головного мозга человека после однократного внутривенного введения магневиста. Были изучены образцы от 5 пациентов с глиальными опухолями при однократном внутривенном введении магневиста в разные моменты времени до операции. Контролем служили образцы 2 пациентов с глиальными опухолями и без внутривенного введения магневиста и других соединений, содержащих гадолиний. Содержание гадолиния в опухолевых тканях анализировалось методом нейтронного активационного анализа. В контрольных образцах гадолиний не обнаружен. Поскольку свободный гадолиний является токсичным, установление факта его накопления в опухолях головного мозга может оказаться значительным для интерпретации различных неожиданных клинических эффектов в будущем.

№ Ҳавола номи
1 1. American College of Radiology Committee on Drugs and Contrast Media. ACR manual on contrast media. – 9th ed. – Reston (Va): American College of Radiology, 2013.
2 2. Amet S., Launay-Vacher V., Clement O. et al. Incidence of nephrogenic systemic fibrosis in patients undergoing dialysis after contrast-enhanced magnetic resonance imaging with gadoliniumbased contrast agents: the Prospective Fibrose Nephrogenique Systemique study // Invest Radiol. – 2014. – Vol. 49, №2. – P. 109-115.
3 3. Caravan P., Ellison J.J., McMurry T.J., Lauffer R.B. Gadolinium (III) chelates as MRI contrast agents: structure, dynamics, and applications // Chem. Rev. – 1999. – Vol. 99, №9. – P. 2293-2352.
4 4. Edelman R.R., Warach S. Magnetic resonance imaging (1) // New Engl. J. Med. – 1993. – Vol. 328, №10. – P. 708-716.
5 5. Edelman R.R., Warach S. Magnetic resonance imaging (2) // New Engl. J. Med. – 1993. – Vol. 328, №11. – P. 785-791.
6 6. Errante Y., Cirimele V., Mallio C.A. et al. Progressive increase of T1 signal intensity of the dentate nucleus on unenhanced magnetic resonance images is associated with cumulative doses of intravenously administered gadodiamide in patients with normal renal function, suggesting dechelation // Invest. Radiol. – 2014. – Vol. 49, №10. – P. 685-690.
7 7. Grobner T. Gadolinium – a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis? // Nephrol. Dial. Transpl. – 2006. – Vol. 21, №4. – P. 1104-1108.
8 8. Hao D., Ai T., Goerner F. et al. MRI contrast agents: basic chemistry and safety // J. Magn. Reson. Imag. – 2012. – Vol. 36, №5. – P. 1060-1071
9 9. High W.A., Ayers R.A., Chandler J. et al. Gadolinium is detectable within the tissue of patients with nephrogenic systemic fibrosis // J. Amer. Acad. Dermatol. – 2007. – Vol. 56, №1. – P. 21-26.
10 10. Kanda T., Ishii K., Kawaguchi H. et al. High signal intensity in the dentate nucleus and globus pallidus on unenhanced T1-weighted MR images: relationship with increasing cumulative dose of a gadoliniumbased contrast material // Radiology. – 2014. – Vol. 270, №3. – P. 834-841.
11 11. McDonald R.J., McDonald J.S., Kallmes D.F. et al. Intracranial gadolinium deposition after contrast-enhanced MR imaging // Radiology. – 2015. Vol. 000. – P. 1-11
12 12. Mednis I.V. Gamma-radiation of radionuclides, used in neutron activation analysis // Reference book. – Riga: Zinatne, 1987.
13 13. Moreau J.F., Droz D., Sabto J. et al. Osmotic nephrosis induced by water-soluble triiodin- ated contrast media in man: a retrospective study of 47 cases // Radiology. – 1975. – Vol. 115, №2. – P. 329-336.
14 14. SPC Magnevist. Summary of Product Characteristics last updated on medicines. – Bayer Limited. 2010.
15 15. White G.W., Gibby W.A., Tweedle M.F. Comparison of Gd(DTPABMA) (Omniscan) Versus Gd(HP-DO3A) (ProHance) Relative to Gadolinium Retention in Human Bone Tissue by Inductively Coupled Plasma Mass Spectroscopy // Invest. Radiol. – 2006. – Vol. 41, №3. – P. 272-278
16 16. Zhou Z., Lu Z.R. Gadolinium-based contrast agents for magnetic resonance cancer imaging // Wil. Interdis. Rev. Nanomed Nanobiotech. – 2013. – Vol. 5, №1. – P. 1-18.
Кутилмоқда