991

Турли фертил ҳолатдаги 42 нафар эркак эякуляти текширилди. Улиностатин
препаратининг қўлланиши, эркаклар спермаси иммунологик характеристикасини
яхшилаши аниқланди. Даволанишдан сўнг сперманинг антипротеолитик хусусияти
камайиб, протеолитик фаоллиги ортиши аниқланди.
 

  • Журнал номиRE-HEALTH
  • Нашр номи2-2019
  • Кўришлар сони 991
  • Ўқишлар сони 951
  • Нашр санаси 15-09-2019
  • Мақола тилиO'zbek
  • Саҳифалар сони11-21
Русский

Исследованы 42 эякулята мужчин с различным состоянием фертильности.
Установлено, что применение препарата улиностатина в качестве иммунокоррегирующего
фактора спермы мужчин способствует улучшению её иммунных характеристик. После
лечения улиностатином у мужчин с нарушением фертильности отмечалось снижение
антипротеолитической и увеличение протеолитической активности спермы.
 

English

42 ejaculates of men with different fertility conditions were examined. It was established
that the use of the drug ulinostatin as an immunocorrecting factor in men sperm contributes to
the improvement of its immune characteristics. After treatment with ulinostatin in men with
impaired fertility, a decrease in antiproteolytic and an increase in sperm proteolytic activity were
noted.
 

Ўзбек

Турли фертил ҳолатдаги 42 нафар эркак эякуляти текширилди. Улиностатин
препаратининг қўлланиши, эркаклар спермаси иммунологик характеристикасини
яхшилаши аниқланди. Даволанишдан сўнг сперманинг антипротеолитик хусусияти
камайиб, протеолитик фаоллиги ортиши аниқланди.
 

№ Муаллифнинг исми Лавозими Ташкилот номи
1 Aleynik V.A. ASMI
2 Babich S.M. ASMI
3 Khodzhimatov G.M. ASMI
4 Ibragimova S.R. ASMI
5 Shokirova S.M. ASMI
№ Ҳавола номи
1 1. Бабаян А.А., Смольникова В.Ю., Николаева М.А., Степанова Е.О., Калинина Е.А. Влияние иммунорегуляторных свойств семенной плазмы на репродуктивную функцию женщин// Гинекология, 2012, №4, С. 80-84 .
2 2. Eggert-Kruse W. et al. Relationship of seminal plasma interleukin (IL)-8 and IL-6 with semen quality //Human reproduction. – 2001. – Т. 16. – №. 3. – С. 517-528.
3 3. Robertson, S.A., Guerin L.R., Bromfield J.J., Branson K.M., Ahlström A.C., Care A.S. Seminal fluid drives expansion of the CD4+ CD25+ T regulatory cell pool and induces tolerance to paternal alloantigens in mice. Biology of reproduction, 2009, 80(5), 1036-1045.
4 4. Kubiczkova L. et al. TGF-β–an excellent servant but a bad master //Journal of translational medicine. – 2012. – Т. 10. – №. 1. – С. 183.
5 5. Johansson M. et al. Semen activates the female immune response during early pregnancy in mice //Immunology. – 2004. – Т. 112. – №. 2. – С. 290-300.
6 6. Jones R. L. et al. TGF-β superfamily expression and actions in the endometrium and placenta //Reproduction. – 2006. – Т. 132. – №. 2. – С. 217-232.
7 7. Yang L., Pang Y., Moses H. L. TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression //Trends in immunology. – 2010. – Т. 31. – №. 6. – С. 220-227.
8 8. Sadat Z., Kalahroudi M. A., Saberi F. The effect of short duration sperm exposure on development of preeclampsia in primigravid women //Iranian Red Crescent Medical Journal. – 2012. – Т. 14. – №. 1. – С. 20.
9 9. Yamane K. et al. Antagonistic effects of TNF-α on TGF-β signaling through downregulation of TGF-β receptor type II in human dermal fibroblasts //The Journal of Immunology. – 2003. – Т. 171. – №. 7. – С. 3855-3862.
10 10. McCaffrey T. A. et al. Transforming growth factor-beta activity is potentiated by heparin via dissociation of the transforming growth factor-beta/alpha 2-macroglobulin inactive complex //The Journal of Cell Biology. – 1989. – Т. 109. – №. 1. – С. 441-448.
11 11. Nelson S. M., Greer I. A. The potential role of heparin in assisted conception //Human Reproduction Update. – 2008. – Т. 14. – №. 6. – С. 623-645.
12 12. Ito K. et al. Effect of Ulinastatin, a human urinary trypsin inhibitor, on the oleic acidinduced acute lung injury in rats via the inhibition of activated leukocytes //Injury. – 2005. – Т. 36. – №. 3. – С. 387-394.
13 13. Molor-Erdene P. et al. Urinary trypsin inhibitor reduces LPS-induced hypotension by suppressing tumor necrosis factor-α production through inhibition of Egr-1 expression //American Journal of Physiology-Heart and Circulatory Physiology. – 2005. – Т. 288. – №. 3. – С. H1265-H1271
14 14. Cao Y. Z. et al. Protective effect of Ulinastatin against murine models of sepsis: inhibition of TNF-α and IL-6 and augmentation of IL-10 and IL-13 //Experimental and Toxicologic Pathology. – 2012. – Т. 64. – №. 6. – С. 543-547.
15 15. Krol J., Kowalski R., Demska-Zakęś K., Hliwa P., Glogowski J. Proteolytic and antiproteolytic activity in the seminal plasma of Eurasian perch (Percafluviatilis L.) during the spawning period. Czech J. Anim. Sci., 2011, vol. 56, no9, 390–397.
Кутилмоқда