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Panaxitriol and its derivatives are biologically active substances isolated from a natural product - red ginseng root. It was found that they are responsible for its main pharmacological properties, namely: cytotoxic, chemoprotective, chemopreventive, antiplatelet and anti-inflammatory. This review will consider the substrate for such a broad action.

  • Название журналаARES
  • Номер выпускаVolume 2, Issue 6
  • Количество просмотров 532
  • Количество прочтений 0
  • Дата публикации 21-03-2024
  • Язык статьиIngliz
  • Страницы776-781
English

Panaxitriol and its derivatives are biologically active substances isolated from a natural product - red ginseng root. It was found that they are responsible for its main pharmacological properties, namely: cytotoxic, chemoprotective, chemopreventive, antiplatelet and anti-inflammatory. This review will consider the substrate for such a broad action.

№ Имя автора Должность Наименование организации
1 Akbarov N.A. student Tashkent Pharmaceutical Institute
№ Название ссылки
1 1. Saito, T .; Matsunaga, H .; Yamamoto, H .; Nagumo, F .; Fujito, H .; Mori, M .; Katano, M. Biol. Pharm. Bull. 1994, 17, C. - 798
2 2. Heedong Yun, Ting-Chao Chou, Huajin Dong, Yuan Tian, Yue-ming Li, and Samuel J. Danishefsky; Total Synthesis as a Resource in Drug Discovery: The First In Vivo Evaluation of Panaxytriol and Its Derivatives, 2005.
3 3. Fay Ng, Heedong Yun, Xiaoguang Lei, Samuel J. Danishefsky, Jed Fahey, Katherine Stephenson, Charles Flexner, Lawrence Lee; (3R, 9R, 10R) –
4 4. Panaxytriol: a molecular-based nutraceutical with possible application to cancer prevention and treatment; Columbia University ,, USA, 2008
5 5. Katano, M .; Yamamoto, H .; Matsunaga, H .; Mori, M .; Takata, K .; Nakamura, M. Gan to Kagaku Ryoho 1990, 17, 1045
6 6. Heedong Yun, Straightforward Synthesis of Panaxytriol: An Active Component of Red Ginseng. The Journal of Organic Chemistry / Heedong Yun, and Samuel J. Danishefsky. -USA2003
7 7. O. Sticher Biochemical, Pharmaceutical, and Medical Perspectives of Ginseng - Web [http://pubs.acs.org/doi/pdf/10.1021/bk-1998-0691.ch016], Phytomedicines of Europe, 2009.
8 8. Glebko L I. Standardization of the quality of ginseng roots and tincture by the content of the sum of ginsenosides. / L. I. Glebko, N. P. Krasovskaya, T. V. Pokushalova, G. Ya. Ilchenko, T. A. Budina // Chemical and pharmaceutical journal. - 2004. - No. 4.- P. 20–23.
9 9. Bushma, M.I.Pharmacology. Part 2: for students of institutions of higher medical education / M.I.Bushma, K.M.Bushma. - Minsk Vysh. shk. 2013.- 464
10 10. C. Chou TC, Multifaceted cytoprotection by synthetic polyacetylenes inspired by the ginseng-derived natural product, panaxytriol. Proceedings of the National Academy of Sciences / Dong H, Zhang X, Lei X, Hartung J, Zhang Y, Lee JH, Wilson RM, Danishefsky SJ, - USA, 2011.
11 11. Constance Lay Lay Saw, Anti-cancer and potential chemopreventive actions of ginseng by activating Nrf2 (NFE2L2) anti-oxidative stress / anti-inflammatory pathways. Chinese Medicine / Wu Q. Tony Hong A. - China, 2010.
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