401

  • Количество прочтений 401
  • Дата публикации 10-06-2020
  • Язык статьиO'zbek
  • Страницы23-29
Ключевые слова
English

This review summarizes the current evidence on the role of cytokines in the pathogenesis of ischemic myocardial damage. It described
the important role of inflammation in the development of coronary heart disease. The role of individual cytokines in the pathogenesis
of coronary artery disease and the most frequent forms of it - angina. It is shown that in patients with coronary heart disease progression
of the disease is due to an imbalance in cytokine system, elevated pro-inflammatory cytokines (TNF, IL-1β, IL-6). Anti-inflammatory
cytokines (IL-4, IL-10) inhibit the secretion of proinflammatory cytokines by limiting excessive intensity of the immune response.
Revealed increasing levels of TGF-β1 as a key cytokine that promotes the development of fibrosis in the wall of the heart and blood
vessels. The interrelation between improving markers of inflammation and the development of coronary heart disease, the predictive
value of these markers of inflammation in patients with stable coronary heart disease: angina of effort of different functional classes.

Ключевые слова
№ Имя автора Должность Наименование организации
1 Alyavi A.L. д.м.н АО « Республиканский специализированный научно-практический медицинский центр терапии и медицинской реабилитации»
2 Tulyaganova D.K. старший научный сотрудник АО « Республиканский специализированный научно-практический медицинский центр терапии и медицинской реабилитации»
3 Nuritdinova S.K. старший преподаватель АО « Республиканский специализированный научно-практический медицинский центр терапии и медицинской реабилитации»
4 Khan .A. младший научный сотрудник АО « Республиканский специализированный научно-практический медицинский центр терапии и медицинской реабилитации»
5 Nazarova .A. младший научный сотрудник АО « Республиканский специализированный научно-практический медицинский центр терапии и медицинской реабилитации»
6 Saidov S.B. младший научный сотрудник АО « Республиканский специализированный научно-практический медицинский центр терапии и медицинской реабилитации»
№ Название ссылки
1 1. Zhou, P., Hua, F., Wang, X. et al. Therapeutic potential of IKK-b inhibitors from natural phenolics for inflammation in cardiovascular diseases. Inflammopharmacol 28, 19–37 (2020). https://doi.org/10.1007/s10787-019-00680-8 2. Raish M (2017) Momordica charantia polysaccharides ameliorate oxidative stress, hyperlipidemia, inflammation, and apoptosis during myocardial infarction by inhibiting the NF-kB signaling pathway. Int J Biol Macromol 97:544–551 3. WorldHealthOrganizationStatisticalInformationSystem (WHOSIS) [Elektronnyy resurs]: Statisticheskaya informatsionnaya sistema Vsemirnoy organizatsii zdravookhraneniya. – rezhim dostupa k zhurn.: http: /www.who.int/ mediacentre/factsheets/fs310/ru/index2.html 4. Gosudarstvennyy nauchno-issledovatel'skiy tsentr profilakticheskoy meditsiny Ministerstva zdravookhraneniya Rossiyskoy Federatsii (GNITS profilakticheskoy meditsiny) [Elektronnyy resurs]: Statisticheskiye materialy po zabolevayemosti i smertnosti. - Samorodskaya I.V., Pustelenin A.V., S.A. Boytsov I.V. Smertnost' i dolya umershikh v ekonomicheski aktivnom vozraste ot prichin, svyazannykh s alkogolem (narkotikami), IM i IBS ot vsekh umershikh v vozraste 15-72 za 2013 god. – rezhim dostupa k zhurn.: http: /www.gnicpm.ru/PublicHealth/326 (data obrashcheniya: 23.12.15). 5. Rekomendatsii po vedeniyu stabil'noy koronarnoy bolezni serdtsa Yevropeyskogo obshchestva kardiologov. – Moskva: 2013. 6. Diagnostika i lecheniye khronicheskoy ishemicheskoy bolezni serdtsa/ Klinicheskiye rekomendatsii. – Moskva: 2013. 7. Armstrong E.J. et al., Inflammatory biomarkers in acute coronary syndromes: part I: introduction and cytokines // Circulation, 2006, 113 (6): e72–75. 8. Fruchart J.-C. Pathophysiology of stages of development of atherosclerosis / Handbook of dyslipidemia and atherosclerosis // France, University of Lille, 2003; Part 1, p. 1–65. 9. Armstrong E.J. et al., Inflammatory biomarkers in acute coronary syndromes: part IV: matrix metalloproteinases and biomarkers of platelet activation // Circulation, 2006, 113 (9): e382–385. 10. Bucova M. et al., C-reactive protein, cytokines and inflammation in cardiovascular diseases //Bratisl. Lek.Listy., 2008, 109 (8): 333–340. 11. Libby P. Inflammation and cardiovascular disease mechanisms. // Am J ClinNutr 2006; 83:456S – 460S. 12. Atrial fibrillation pathophysiology: implications for management / Y.K. Iwasaki et al.,] // Circulation. 2011; 124: 2264–2274. 13. Pavlov O.N. Svyaz' vospaleniya s rostom titra antitel k helicobacterpylori pri ostrom koronarnom sindrome// Rossiyskiy kardiologicheskiy zhurnal №6(92)/2011. – S.43-46. 14. Gusev Ye.YU., Osipenko A.V. Immunologiya sistemnogo vospaleniya / Immunologiya Urala. – 2001. – T.1, №1. – S.4-8. 15. Belotskiy, S.M., Avtalion, R.R. Vospaleniye. Mobilizatsiya kletok i klinicheskiye effekty. – M.: Izdatel'stvo BI- NOM, 2008. – 240 s. 16. Rukovodstvo po kardiologii v chetyrekh tomakh. Tom 2: Metody diagnostiki serdechno-sosudistykh zabolevaniy /Pod redaktsiyey akademika Ye. I. Chazova. – M.: Praktika, 2014. 17. Sukhija R. et al., Inflammatory markers, angiographic severity of coronary artery disease, and patient outcome // Am. J. Cardiol., 2007, 99 (7): 879–884. 18. Boekholdt S.M. et al., IL-8 plasma concentrations and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk prospective population study // Arterioscler. Thromb.Vasc.Biol., 2004, 24 (8): 1503–1508. 19. Ragino YU.I. i soavt., Aktivnost' vospalitel'no-destruktivnykh izmeneniy v protsesse formirovaniya nestabil'noy ateroskleroticheskoy blyashki // Kardiologiya, 2007; 9: 62–67. 20. Hansson GK. Inflammation, atherosclerosis and coronary artery disease.//NEnglJMed 2005; 352 (16): 1685–95. 21. Koval'chuk L.V. i soavt., Klinicheskaya immunologiya i allergologiya s osnovami obshchey immunologii, - GEOTARMedia, 2014. – 640s. 22. Packard R, Libby P. Inflammation in atherosclerosis: from vascular biology to biomarker discovery and risk prediction. //Clin.Chem. 2008; 54(1): 24-38. 23. BozkurtB., KribbsS.B., ClubbF.J. etal. Pathophysiologically relevant concentrations of tumor necrosis factor-a promote progressive left ventricular dysfunction and remodeling in rats. // Circulation 1998; 97: 1382-91. 24. TeplyakovA.T. Khronicheskayaserdechnayanedostatochnost. Tsitokinovayaekspressiya, immunnayaaktivatsiya I zaschitaorganovmisheney. Tomsk: Izd-vo Tom. Un-ta, 2012. rp. 294. 25. Anker S.D. et al., Elevation soluble CD14 receptore and altered cytokines in chronic heart failure // Am. J. Cardiol. 1997. no. 79. pp. 1426–1430. 26. Zakirova, N.E. Immunovospalitel'nyye reaktsii pri ishemicheskoy bolezni serdtsa / N.E. Zakirova, N.KH. Khafizov, A.N. Zakirova // Ratsional'naya farmakoterapiya v kardiologii.-2007.- №2.-S.16-19. 27. Paleyev, F.N. Izmeneniya interleykina-6 pri razlichnykh formakh ishemicheskoy bolezni serdtsa //F.N.Paleyev, I.S. Abudeyeva, O.V. Moskalets, I.S. Belokopytova / Kardiologiya.- 2010.-№ 2.- S. 69-72. 28. RathanN., HemingwayC.A., AlizadehA.A., StephensA.C., BoldrickJ.C., OraguiEE, McCabeC., WelchS.B., WhitneyA., O’Gara 28. РathanN., HemingwayC.A., AlizadehA.A., StephensA.C., BoldrickJ.C., OraguiEE, McCabeC., WelchS.B., WhitneyA., O’GaraP., NadelS., RelmanD.A., HardingS.E., LevinM. Roleofinterleukin 6 inmyocardialdysfunctionofmeningococcalsepticshock //Lancet. 2004. no. 363. pp. 203–209. 29. Inoue T., Komoda H., Nonaka M. et al. Interleukin-8 as an independent predictor of long-term clinical outcome in patients with coronary artery disease // Int. J. Cardiol. 2008. V. 124. № 3. P. 319–325. 30. Kukharchuk V.V., Zykov K.A., Masenko V.P. i dr. Dinamika vospalitel'nogo protsessa u bol'nykh s ostrym koronarnym sindromom i bol'nykh so stabil'noy stenokardiyey. Kardiolvestn // 2007; 2. 31. KetlinskiyS.A., Simbirtsev A.S. Tsitokiny — SPb., Foliant 2008.— 552 s. 32. Prasolov A.V., Knyazeva L.A., Knyazeva L.I., Zhukova L.A. Izmeneniye pokazateley tsitokinovogo statusa u bol'nykh IBS: stabil'noy stenokardiyey napryazheniya II-III funktsional'nogo klassa v zavisimosti ot terapii // Vestnik novykh meditsinskikh tekhnologiy – 2009 – T.KHVI, №2 – s.146-147. 33. Zakirova A.N., Mukhametrakhimova A.R., Zakirova N.E. Sostoyaniye sistolicheskoy funktsii levogo zheludochka i aktivnost' provospalitel'nykh tsitokinov pri ostrom infarkte miokarda. // ZhurnalSerdechnayanedostatochnost' 2005;6(4):162-
В ожидании