Knowledge of the pharmacokinetic and pharmacodynamic profile of an antibacterial drug is critical for optimizing the dosage regimen. The strategy of individual selection of the dosage regimen taking into account the principles of pharmacokinetics and pharmacodynamics can be especially effective in patients with expectedly altered pharmacokinetic parameters and in infections caused by bacterial strains with low sensitivity to antibiotics. The review presents current concepts of the pharmacokinetic and pharmacodynamic profile of antibacterial drugs most frequently used in pediatrics and their relationship with the clinical efficacy of the therapy
Knowledge of the pharmacokinetic and pharmacodynamic profile of an antibacterial drug is critical for optimizing the dosage regimen. The strategy of individual selection of the dosage regimen taking into account the principles of pharmacokinetics and pharmacodynamics can be especially effective in patients with expectedly altered pharmacokinetic parameters and in infections caused by bacterial strains with low sensitivity to antibiotics. The review presents current concepts of the pharmacokinetic and pharmacodynamic profile of antibacterial drugs most frequently used in pediatrics and their relationship with the clinical efficacy of the therapy
| № | Имя автора | Должность | Наименование организации |
|---|---|---|---|
| 1 | Usmonova F.T. | Assistant | ASMI |
| № | Название ссылки |
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| 1 | 1.Demetskaya A. Children and Medicines // Pharmacist Practitioner. -2015. -No6. [Demetskaya A. Children and Medicines. Farmatsevt praktik. 2015;(6). (In Russ).] Available at: http://fp.com.ua/articles/8005-5013-2/ Link active on 12.01.2018.2.Anderson BJ, Holford NH. Tips and traps analyzing pediatric PK data. Paediatr Anaesth. 2011;21(3):222–237. doi: 10.1111/ j.1460-9592.2011.03536.x.3.Downes KJ, Hahn A, Wiles J, et al. Dose optimisation of antibiotics in children: application of pharmacokinetics/pharmacodynamics in paediatrics. Int J Antimicrob Agents. 2014;43(3):223–230. doi: 10.1016/j.ijantimicag.2013.11.006.4.Yakovlev SV. Pharmacodynamic and pharmacokinetic approaches to optimising the use of lomefloxacin // Antibiotics and chemotherapy. -2018. -Vol. 43. -No. 10 -P. 42–45. (In Russ).]5.Trivedi A, Lee RE, Meibohm B. Applications of pharmacometrics in the clinical development and pharmacotherapy of anti-infectives. Expert Rev Clin Pharmacol. 2013;6(2):159–170. doi:10.1586/ecp.13.6. |